Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/31791
Title: Children’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease
Authors: LUYTEN, Leen 
DOCKX, Yinthe 
PROVOST, Eline 
MADHLOUM, Narjes 
SLEURS, Hanne 
NEVEN, Kristof 
JANSSEN, Bram 
BOVE, Hannelore 
Chainiaux, Florence
Gerrits, Nele
Lefebvre, Wouter
PLUSQUIN, Michelle 
Vanpoucke, Charlotte
DE BOEVER, Patrick 
NAWROT, Tim 
Issue Date: 2020
Publisher: BMC
Source: BMC MEDICINE, 18 (1) (Art N° 128)
Abstract: Background Particulate matter exposure during in utero life may entail adverse health outcomes later in life. The microvasculature undergoes extensive, organ-specific prenatal maturation. A growing body of evidence shows that cardiovascular disease in adulthood is rooted in a dysfunctional fetal and perinatal development, in particular that of the microcirculation. We investigate whether prenatal or postnatal exposure to PM2.5 (particulate matter with a diameter <= 2.5 mu m) or NO2 is related to microvascular traits in children between the age of four and six. Methods We measured the retinal microvascular diameters, the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE), and the vessel curvature by means of the tortuosity index (TI) in young children (mean [SD] age 4.6 [0.4] years), followed longitudinally within the ENVIRONAGE birth cohort. We modeled daily prenatal and postnatal PM2.5 and NO2 exposure levels for each participant's home address using a high-resolution spatiotemporal model. Results An interquartile range (IQR) increase in PM2.5 exposure during the entire pregnancy was associated with a 3.85-mu m (95% CI, 0.10 to 7.60; p = 0.04) widening of the CRVE and a 2.87-mu m (95% CI, 0.12 to 5.62; p = 0.04) widening of the CRAE. For prenatal NO2 exposure, an IQR increase was found to widen the CRVE with 4.03 mu m (95% CI, 0.44 to 7.63; p = 0.03) and the CRAE with 2.92 mu m (95% CI, 0.29 to 5.56; p = 0.03). Furthermore, a higher TI score was associated with higher prenatal NO2 exposure. We observed a postnatal effect of short-term PM2.5 exposure on the CRAE and a childhood NO2 exposure effect on both the CRVE and CRAE. Conclusions Our results link prenatal and postnatal air pollution exposure with changes in a child's microvascular traits as a fundamental novel mechanism to explain the developmental origin of cardiovascular disease.
Notes: Nawrot, TS (corresponding author), Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.; Nawrot, TS (corresponding author), Leuven Univ, Dept Publ Hlth & Primary Care Occupat & Environm, Leuven, Belgium.
tim.nawrot@uhasselt.be
Other: Nawrot, TS (corresponding author), Nawrot, T;S (corresponding author); Leuven Univ, Dept Publ Hlth & Primary Care Occupat & Environm, Leuven, Belgium. tim.nawrot@uhasselt.be
Keywords: CRAE;CRVE;Tortuosity index;Air pollution;Child health
Document URI: http://hdl.handle.net/1942/31791
ISSN: 1741-7015
e-ISSN: 1741-7015
DOI: 10.1186/s12916-020-01586-x
ISI #: WOS:000537119500001
Rights: © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Category: A1
Type: Journal Contribution
Validations: ecoom 2021
Appears in Collections:Research publications

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