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http://hdl.handle.net/1942/31972
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DC Field | Value | Language |
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dc.contributor.author | PIETERS, Zoe | - |
dc.contributor.author | Strong, Mark | - |
dc.contributor.author | Pitzer, Virginia E. | - |
dc.contributor.author | Beutels, Philippe | - |
dc.contributor.author | Bilcke, Joke | - |
dc.date.accessioned | 2020-09-25T10:08:24Z | - |
dc.date.available | 2020-09-25T10:08:24Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-09-09T11:22:59Z | - |
dc.identifier.citation | MEDICAL DECISION MAKING, 40 (5) , p. 669 -679 (Art N° 0272989X20937253) | - |
dc.identifier.uri | http://hdl.handle.net/1942/31972 | - |
dc.description.abstract | Background. Threshold analysis is used to determine the threshold value of an input parameter at which a health care strategy becomes cost-effective. Typically, it is performed in a deterministic manner, in which inputs are varied one at a time while the remaining inputs are each fixed at their mean value. This approach will result in incorrect threshold values if the cost-effectiveness model is nonlinear or if inputs are correlated.Objective. To propose a probabilistic method for performing threshold analysis, which accounts for the joint uncertainty in all input parameters and makes no assumption about the linearity of the cost-effectiveness model.Methods. Three methods are compared: 1) deterministic threshold analysis (DTA); 2) a 2-level Monte Carlo approach, which is considered the gold standard; and 3) a regression-based method using a generalized additive model (GAM), which identifies threshold values directly from a probabilistic sensitivity analysis sample.Results. We applied the 3 methods to estimate the minimum probability of hospitalization for typhoid fever at which 3 different vaccination strategies become cost-effective in Uganda. The threshold probability of hospitalization at which routine vaccination at 9 months with catchup campaign to 5 years becomes cost-effective is estimated to be 0.060 and 0.061 (95% confidence interval [CI], 0.058-0.064), respectively, for 2-level and GAM. According to DTA, routine vaccination at 9 months with catchup campaign to 5 years would never become cost-effective. The threshold probability at which routine vaccination at 9 months with catchup campaign to 15 years becomes cost-effective is estimated to be 0.092 (DTA), 0.074 (2-level), and 0.072 (95% CI, 0.069-0.075) (GAM). GAM is 430 times faster than the 2-level approach.Conclusions. When the cost-effectiveness model is nonlinear, GAM provides similar threshold values to the 2-level Monte Carlo approach and is computationally more efficient. DTA provides incorrect results and should not be used. | - |
dc.description.sponsorship | Financial support for this study was provided in part by grants from the Bill and Melinda Gates Foundation (OPP1116967, OPP1151153) (VEP), Research Foundation–Flanders (JB), and the Methusalem financing program of the Flemish government (ZP). The funding agreements ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.rights | The Author(s) 2020. Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0272989X20937253 journals.sagepub.com/home/mdm | - |
dc.subject.other | deterministic sensitivity analysis | - |
dc.subject.other | Monte Carlo approach | - |
dc.subject.other | probabilistic sensitivity analysis | - |
dc.subject.other | probabilistic threshold analysis | - |
dc.title | A Computationally Efficient Method for Probabilistic Parameter Threshold Analysis for Health Economic Evaluations | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 679 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 669 | - |
dc.identifier.volume | 40 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Pieters, Z (corresponding author), Univ Antwerp, Hasselt Univ, Data Sci Inst, I BioStat, DS-243,Univ Pl 1, B-2610 Antwerp, Belgium. | - |
dc.description.notes | zoe.pieters@uantwerpen.be | - |
dc.description.other | Pieters, Z (corresponding author), Univ Antwerp, Hasselt Univ, Data Sci Inst, I BioStat, DS-243,Univ Pl 1, B-2610 Antwerp, Belgium. zoe.pieters@uantwerpen.be | - |
local.publisher.place | 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1177/0272989X20937253 | - |
dc.identifier.pmid | 32627657 | - |
dc.identifier.isi | WOS:000546012800001 | - |
dc.contributor.orcid | PIETERS, Zoe/0000-0002-7288-4461; Strong, Mark/0000-0003-1486-8233; | - |
dc.contributor.orcid | Beutels, Philippe/0000-0001-5034-3595 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Pieters, Zoe] Hasselt Univ, Data Sci Inst, I BioStat, Hasselt, Limburg, Belgium. | - |
local.description.affiliation | [Pieters, Zoe; Beutels, Philippe; Bilcke, Joke] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Ctr Hlth Econ Res & Modeling Infect Dis CHERMID, Antwerp, Belgium. | - |
local.description.affiliation | [Strong, Mark] Univ Sheffield, Sch Hlth & Related Res ScHARR, Sheffield, S Yorkshire, England. | - |
local.description.affiliation | [Pitzer, Virginia E.] Yale Univ, Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA. | - |
local.uhasselt.international | yes | - |
item.contributor | PIETERS, Zoe | - |
item.contributor | Strong, Mark | - |
item.contributor | Pitzer, Virginia E. | - |
item.contributor | Beutels, Philippe | - |
item.contributor | Bilcke, Joke | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.fullcitation | PIETERS, Zoe; Strong, Mark; Pitzer, Virginia E.; Beutels, Philippe & Bilcke, Joke (2020) A Computationally Efficient Method for Probabilistic Parameter Threshold Analysis for Health Economic Evaluations. In: MEDICAL DECISION MAKING, 40 (5) , p. 669 -679 (Art N° 0272989X20937253). | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0272-989X | - |
crisitem.journal.eissn | 1552-681X | - |
Appears in Collections: | Research publications |
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