Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/322
Title: | Patterns of opportunistic infections in patients with HIV infection | Authors: | Finkelstein, Dianne M. Williams, Paige L. MOLENBERGHS, Geert Feinberg, Judith Powderly, William G. Kahn, James C. Dolin, Raphael Cotton, Deborah |
Issue Date: | 1996 | Source: | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 12(1). p. 38-45 | Abstract: | The pattern of the development of opportunistic infections (OIs) in HIV-infected patients was evaluated, based on a cohort of 1,530 patients enrolled in two AIDS Clinical Trials Group anti-retroviral studies. We quantified the increase in risk of OIs associated with the occurrence of a previous OI. This assessment was based on the observed event rates of the more common AIDS-defining OIs: Pneumocystis carinii pneumonia (PCP), Mycobacterium avium complex (MAC), cytomegalovirus (CMV), and a systemic mycosis. Additionally, for each OI, we assessed the relative risks associated with a history of prior OIs, changes in CD4 levels, and baseline prognostic factors. We found that the occurrence of each of these OIs increased the risk of subsequent OIs, even after adjusting for the CD4 count. Specifically, the occurrence of PCP significantly increased the risk of MAC and CMV, and somewhat increased the risk of systemic mycoses. Diagnosis with MAC was associated with an increased risk of subsequent CMV, whereas the occurrence of CMV increased the risk of MAC. Finally, once patients were diagnosed with a systemic mycosis, they were at a somewhat increased risk of subsequently developing MAC or CMV. Although current practice for determining the timing and initiation of prophylactic therapies relies chiefly on CD4 count, the occurrence of specific AIDS-defining OIs in patients with HIV infection should also be taken into account in making decisions regarding prophylaxis strategies. | Keywords: | opportunistic infections; pneumocystis carinii pneumonia; mycobacterium avium complex; cytomegalovirus infection; systemic mycosis; relative risk; prophylactic therapies; proportional hazards model | Document URI: | http://hdl.handle.net/1942/322 | Link to publication/dataset: | http://journals.lww.com/jaids/Fulltext/1996/05010/Patterns_of_Opportunistic_Infections_in_Patients.6.aspx | Rights: | © Lippincott-Raven Publishers. | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.