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http://hdl.handle.net/1942/32647
Title: | Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? | Authors: | Goërtz, Yvonne VAN HERCK, Maarten Delbressine, Jeannet Vaes, Anouk Meys, Roy Machado, Felipe Houben-Wilke, Sarah BURTIN, Chris Posthuma, Rein Franssen, Frits Van Loon, Nicole Hajian, Bita Spies, Yvonne Vijlbrief, Herman Van't Hul, Alex Janssen, Daisy SPRUIT, Martijn A. |
Issue Date: | 2020 | Publisher: | European Respiratory Society | Source: | ERJ open research, 6 (4) (Art N° 00542-2020) | Abstract: | Background: Many patients with COVID-19 did not require hospitalisation, nor underwent COVID-19 testing. There is anecdotal evidence that patients with "mild" COVID-19 may complain about persistent symptoms, even weeks after the infection. This suggests that symptoms during the infection may not resolve spontaneously. The objective of this study was to assess whether multiple relevant symptoms recover following the onset of symptoms in hospitalised and nonhospitalised patients with COVID-19. Methods: A total of 2113 members of two Facebook groups for coronavirus patients with persistent complaints in the Netherlands and Belgium, and from a panel of people who registered on a website of the Lung Foundation Netherlands, were assessed for demographics, pre-existing comorbidities, health status, date of symptoms onset, COVID-19 diagnosis, healthcare utilisation, and the presence of 29 symptoms at the time of the onset of symptoms (retrospectively) and at follow-up (mean±SD 79±17 days after symptoms onset). Results: Overall, 112 hospitalised patients and 2001 nonhospitalised patients (confirmed COVID-19, n=345; symptom-based COVID-19, n=882; and suspected COVID-19, n=774) were analysed. The median number of symptoms during the infection reduced significantly over time (median (interquartile range) 14 (11-17) versus 6 (4-9); p<0.001). Fatigue and dyspnoea were the most prevalent symptoms during the infection and at follow-up (fatigue: 95% versus 87%; dyspnoea: 90% versus 71%). Conclusion: In previously hospitalised and nonhospitalised patients with confirmed or suspected COVID-19, multiple symptoms are present about 3 months after symptoms onset. This suggests the presence of a "post-COVID-19 syndrome" and highlights the unmet healthcare needs in a subgroup of patients with "mild" or "severe" COVID-19. | Keywords: | Previously hospitalised and nonhospitalised #COVID19 patients can still have multiple persistent symptoms 3 months after the onset of infection-related symptoms. This provides the first evidence for a “post-COVID-19 syndrome” #longCOVID | Document URI: | http://hdl.handle.net/1942/32647 | e-ISSN: | 2312-0541 | DOI: | 10.1183/23120541.00542-2020 | ISI #: | 000603682700109 | Rights: | Copyright ©ERS 2020 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Goërtz , Van Herck et al 2020 ERJOR.pdf | Published version | 882.04 kB | Adobe PDF | View/Open |
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