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http://hdl.handle.net/1942/3283
Title: | Prospects for T cell vaccination in multiple sclerosis | Authors: | MEDAER, Rob STINISSEN, Piet ZHANG, JINGWU RAUS, Jef |
Issue Date: | 1997 | Publisher: | ADIS INTERNATIONAL LTD | Source: | BIODRUGS, 8(1). p. 1-5 | Abstract: | Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP) are thought to play an important role in the pathogenesis of this disease, it was assumed that inactivation or depletion of this pathogenic T cell subset may have therapeutic effects in multiple sclerosis. We have recently reported that T cell vaccination, i.e. immunisation with attenuated autologous MBP-reactive T cell clones, leads to the depletion of the MBP-reactive T cells. Furthermore, this approach induced favourable clinical effects in the treated patients, encouraging further studies of T cell vaccination in multiple sclerosis. | Notes: | LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM.Medaer, R, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. | Document URI: | http://hdl.handle.net/1942/3283 | ISI #: | A1997XJ48500001 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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