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Title: | The effect of universal infant vaccination on the prevalence of hepatitis B immunity in adult solid organ transplant candidates | Authors: | KOC, Ozgur Kuypers, Dirk Dupont, Lieven J. Vos, Robin Van Keer, Jan M. Van Cleemput, Johan ROBAEYS, Geert Oude Lashof, Astrid Kramer, Matthijs Verleden, Geert Verbeek, Jef Nevens, Frederik |
Issue Date: | 2021 | Publisher: | WILEY | Source: | Journal of viral hepatitis, 28 (1), p. 105-111 | Abstract: | Background Hepatitis B virus (HBV) immunity is recommended to optimize outcomes after solid organ transplantation (SOT). This study assessed the prevalence and predictors of HBV immunity at the time patients were placed on transplant waiting list over a period from 1997 to 2019 in a low HBV endemic region. Methods Data were obtained from the University Hospitals Leuven transplant database. Minors and patients with past/current HBV infection were excluded. From 1986, Belgian patients are covered by the universal infant vaccination; therefore, birth cohort was stratified in those born >= 1986 vs The study population consisted of 3297 SOT candidates. HBV immunity rate was superior in renal transplant candidates (55.3%), and this number was 21.5%, 15.4% and 16.8% for liver, cardiac and pulmonary transplant candidates, respectively,P < .001. Among liver transplant candidates, HBV immunity rate was 14.8% in decompensated cirrhotic patients and 27.9% in those without advanced cirrhosis (P < .001). The overall immunity rate increased from 19.3% in period 1997-2008 to 32.8% in 2009-2019,P < .001. In multivariable analyses, younger age (odds ratio (OR) 95% confidence interval (CI): 0.97-0.98,P < .001) and birth cohort >= 1986 (OR 95% CI: 1.18-2.66,P = .006) were associated with increased HBV immunity. Conclusion An increase in HBV immunity was observed over a 20-year period related to the introduction of universal infant HBV vaccination. Nevertheless, this study highlights the low overall HBV immunity at the time of listing for organ transplantation and points out the need of an increased awareness and vaccination strategy at an early disease stage. | Notes: | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. ozgur.koc@uhasselt.be |
Other: | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. ozgur.koc@uhasselt.be | Keywords: | Abbreviations: BMI, body mass index;CI, confidence interval;HBsAg, hepatitis B surface antigen;HBV, hepatitis B virus;HCV, hepatitis C virus;HLA, human leucocyte antigen;OR, odds ratio;SOT, solid organ transplant | Document URI: | http://hdl.handle.net/1942/32847 | ISSN: | 1352-0504 | e-ISSN: | 1365-2893 | DOI: | 10.1111/jvh.13414 | ISI #: | WOS:000577707400001 | Rights: | 2020 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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Journal of Viral Hepatitis - 2020 - Koc - The effect of universal infant vaccination on the prevalence of hepatitis B.pdf | Published version | 503 kB | Adobe PDF | View/Open |
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