Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/33065
Title: | Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability | Authors: | Berkvens, Jessica Majoie, Marian Mergler, Sandra Beerhorst, Kim Verschuure, Pauline Tan, In VAN DEN BERGH, Joop |
Issue Date: | 2020 | Publisher: | ELSEVIER | Source: | EPILEPSY RESEARCH, 167 (Art N° 106461) | Abstract: | Objective: The main objective of this cohort study is to determine the prevalence and incidence of morphometric vertebral fractures (VFs) over 7 years follow-up, in institutionalized adults with refractory epilepsy and intellectual disability (ID). Methods: Dual-energy X-ray Absorptiometry (DXA) and Vertebral Fracture Assessment (VFA) were performed in 2009 and 2016. Vertebrae T4-L4 were assessed using quantitative morphometry. Severity of VFs was graded as 1 (mild; 20-25% reduction in height), 2 (moderate; 25-40% reduction) or 3 (severe; >40% reduction) according to the method described by Genant. Prevalent VFs were analyzed at baseline. VFs (grade 1, 2 or 3) present at follow-up, but not at baseline, were considered new VFs. Worsening VFs were defined as VFs with at least one grade deterioration at follow-up, compared to baseline (grade 1 to 2 or 3, or grade 2 to 3). Patients were treated with anti-osteoporosis treatment according to the Dutch guideline. Results: Baseline and follow-up DXA and VFA could be obtained in 141 patients (87 male) aged between 18-79 years old (mean 44.8 +/- 15.7). At baseline, 56 patients had at least one prevalent VF. Patients with a prevalent VF were significantly older than patients without (49.2 +/- 13.7 vs 41.9 +/- 16.4, p < .01). After 7 years follow-up, 38 new VFs occurred in 27 patients and 15 patients had a worsening VF, leading to an overall cumulative incidence of 27.0%. VF incidence was significantly higher in patients with at least one prevalent VF at baseline (48.2% vs 12.9%, respectively, p < .01) compared to no VF. Significance: In adults with refractory epilepsy VFA is challenging, due to physical and behavioral aspects, resulting in a substantial proportion of unevaluable vertebrae and scans. Nevertheless, 40% of the patients had a VF at baseline and after 7 years follow-up, 27% had at least one new and/or worsening VF despite adequate anti-osteoporosis treatment. | Notes: | Berkvens, J (corresponding author), Epilepsy Ctr Kempenhaeghe, Dept Residential Care, POB 61, NL-5590 AB Heeze, Netherlands. BerkvensJ@Kempenhaeghe.nl |
Other: | Berkvens, J (corresponding author), Epilepsy Ctr Kempenhaeghe, Dept Residential Care, POB 61, NL-5590 AB Heeze, Netherlands. BerkvensJ@Kempenhaeghe.nl | Keywords: | Anti-epileptic drugs (AEDs);Bisphosphonates;Bone mineral density (BMD);Dual-energy X-ray absorptiometry (DXA);Osteoporosis;Vertebral Fractures Assessment (VFA) | Document URI: | http://hdl.handle.net/1942/33065 | ISSN: | 0920-1211 | e-ISSN: | 1872-6844 | DOI: | 10.1016/j.eplepsyres.2020.106461 | ISI #: | WOS:000587830900028 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0920121120305118-main.pdf Restricted Access | Published version | 581.08 kB | Adobe PDF | View/Open Request a copy |
WEB OF SCIENCETM
Citations
2
checked on Jul 13, 2024
Page view(s)
36
checked on Sep 6, 2022
Download(s)
6
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.