Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33113
Title: The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review
Authors: EVENS, Lize 
BELIEN, Hanne 
DELUYKER, Dorien 
BRONCKAERS, Annelies 
GERVOIS, Pascal 
HENDRIKX, Marc 
BITO, Virginie 
Issue Date: 2020
Publisher: HINDAWI LTD
Source: Stem Cells International, 2020 (Art N° 8886612)
Abstract: Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases. However, stem cell engraftment and survival are still challenging due to an unfavorable transplantation environment. Advanced glycation end-products (AGEs) can contribute to the generation of these harmful conditions. AGEs are a heterogeneous group of glycated products, nonenzymatically formed when proteins and/or lipids become glycated and oxidized. Our typical Western diet as well as cigarettes contain high AGEs content. AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations. Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing. Therefore, this systematic review provides a clear overview of the effects of glycated proteins on cell viability in various types of primary isolated stem cells used in regenerative medicine.
Notes: Bito, V (corresponding author), Hasselt Univ, Biomed BIOMED Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium.
virginie.bito@uhasselt.be
Other: Bito, V (corresponding author), Hasselt Univ, Biomed BIOMED Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. virginie.bito@uhasselt.be
Document URI: http://hdl.handle.net/1942/33113
ISSN: 1687-966X
e-ISSN: 1687-9678
DOI: 10.1155/2020/8886612
ISI #: WOS:000597357900002
Rights: Copyright © 2020 Lize Evens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Category: A1
Type: Journal Contribution
Validations: ecoom 2021
Appears in Collections:Research publications

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