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http://hdl.handle.net/1942/33129
Title: | The Clinical Impact of Rapid Molecular Microbiological Diagnostics for Pathogen and Resistance Gene Identification in Patients With Sepsis: A Systematic Review | Authors: | D'ONOFRIO, Valentino Salimans, Lene Bedenic, Branka Cartuyvels, Reinoud Barisic, Ivan GYSSENS, Inge |
Issue Date: | 2020 | Publisher: | OXFORD UNIV PRESS INC | Source: | Open Forum Infectious Diseases, 7 (10) (Art N° ofaa352) | Abstract: | Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared with blood cultures. PubMed was searched for clinical studies using either whole blood directly or after short-term incubation. Twenty-five articles were retrieved describing the outcomes of 8 different MDx. Three interventional studies showed a significant increase in appropriateness of antimicrobial therapy and a nonsignificant change in time to appropriate therapy. Impact on mortality was conflicting. Length of stay was significantly lower in 2 studies. A significant decrease in antimicrobial cost was demonstrated in 6 studies. The limitations of this systematic review include the low number and observed heterogeneity of clinical studies. In conclusion, potential benefits of MDx regarding antimicrobial management and some patient outcomes were reported. More rigorous intervention studies are needed focusing on the direct benefits for patients. | Notes: | Gyssens, IC (corresponding author), Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands. inge.gyssens@radboudumc.nl |
Other: | Gyssens, IC (corresponding author), Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands. inge.gyssens@radboudumc.nl | Keywords: | antimicrobial therapy;antimicrobial therapy;bacteremia;bacteremia;molecular microbiological diagnostics;molecular microbiological diagnostics;patient outcomes;patient outcomes | Document URI: | http://hdl.handle.net/1942/33129 | ISSN: | 2328-8957 | e-ISSN: | 2328-8957 | DOI: | 10.1093/ofid/ofaa352 | ISI #: | WOS:000593126300006 | Rights: | © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com DOI: 10.1093/ofid/ofaa35 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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