Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33129
Title: The Clinical Impact of Rapid Molecular Microbiological Diagnostics for Pathogen and Resistance Gene Identification in Patients With Sepsis: A Systematic Review
Authors: D'ONOFRIO, Valentino 
Salimans, Lene
Bedenic, Branka
Cartuyvels, Reinoud
Barisic, Ivan
GYSSENS, Inge 
Issue Date: 2020
Publisher: OXFORD UNIV PRESS INC
Source: Open Forum Infectious Diseases, 7 (10) (Art N° ofaa352)
Abstract: Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared with blood cultures. PubMed was searched for clinical studies using either whole blood directly or after short-term incubation. Twenty-five articles were retrieved describing the outcomes of 8 different MDx. Three interventional studies showed a significant increase in appropriateness of antimicrobial therapy and a nonsignificant change in time to appropriate therapy. Impact on mortality was conflicting. Length of stay was significantly lower in 2 studies. A significant decrease in antimicrobial cost was demonstrated in 6 studies. The limitations of this systematic review include the low number and observed heterogeneity of clinical studies. In conclusion, potential benefits of MDx regarding antimicrobial management and some patient outcomes were reported. More rigorous intervention studies are needed focusing on the direct benefits for patients.
Notes: Gyssens, IC (corresponding author), Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
inge.gyssens@radboudumc.nl
Other: Gyssens, IC (corresponding author), Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands. inge.gyssens@radboudumc.nl
Keywords: antimicrobial therapy;antimicrobial therapy;bacteremia;bacteremia;molecular microbiological diagnostics;molecular microbiological diagnostics;patient outcomes;patient outcomes
Document URI: http://hdl.handle.net/1942/33129
ISSN: 2328-8957
e-ISSN: 2328-8957
DOI: 10.1093/ofid/ofaa352
ISI #: WOS:000593126300006
Rights: © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com DOI: 10.1093/ofid/ofaa35
Category: A1
Type: Journal Contribution
Validations: ecoom 2021
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
ofaa352.pdfPublished version277.3 kBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations

22
checked on Mar 23, 2024

Page view(s)

20
checked on Sep 6, 2022

Download(s)

12
checked on Sep 6, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.