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http://hdl.handle.net/1942/33245
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DC Field | Value | Language |
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dc.contributor.author | Kawashima, Hideyuki | - |
dc.contributor.author | Tomaniak, Mariusz | - |
dc.contributor.author | Ono, Masafumi | - |
dc.contributor.author | Wang, Rutao | - |
dc.contributor.author | Hara, Hironori | - |
dc.contributor.author | Gao, Chao | - |
dc.contributor.author | Takahashi, Kuniaki | - |
dc.contributor.author | Sharif, Faisal | - |
dc.contributor.author | Thury, Attila | - |
dc.contributor.author | Suryapranata, Harry | - |
dc.contributor.author | Walsh, Simon | - |
dc.contributor.author | Cotton, James | - |
dc.contributor.author | Carrie, Didier | - |
dc.contributor.author | Sabate, Manel | - |
dc.contributor.author | Steinwender, Clemens | - |
dc.contributor.author | Leibundgut, Gregor | - |
dc.contributor.author | Wykrzykowska, Joanna | - |
dc.contributor.author | de Winter, Robbert J. | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Juni, Peter | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2021-01-29T15:00:47Z | - |
dc.date.available | 2021-01-29T15:00:47Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-01-26T10:31:33Z | - |
dc.identifier.citation | The American journal of cardiology, 138 , p. 1 -10 | - |
dc.identifier.issn | 00029149 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33245 | - |
dc.description.abstract | Patients undergoing staged percutaneous coronary intervention (SPCI) are exposed to extended duration of antiplatelet therapy, and a novel aspirin-free antiplatelet regimen after SPCI should be specifically evaluated among these patients. This is a prespecified substudy of the GLOBAL LEADERS which is a randomized, open-label trial, comparing an experimental regimen of 1-month dual antiplatelet therapy (DAPT; ticagrelor and aspirin) followed by 23-month ticagrelor monotherapy to a reference regimen of 12-month DAPT followed by 12-month aspirin monotherapy. Patients were stratified according to whether or not SPCI was performed. The impact of the timing of SPCI on clinical outcomes was also investigated. Of 15,968 randomized patients, 1,651 patients underwent SPCI within 3 months. These patients with SPCI had a significantly higher risk of bleeding and ischemic endpoints than those without SPCI. In patients undergoing SPCI, the primary endpoint (composite of all-cause death or new Q-wave myocardial infarction at 2 years) and secondary safety endpoint (Bleeding Academic Research Consortium [BARC]-defined bleeding 3 or 5) were similar in the 2 regimens. However, in patients presenting with acute coronary syndrome (ACS), the experimental regimen reduced a risk of BARC 3 or 5 bleeding (1.8% vs 4.5%; HR 0.387; 95% CI 0.179 to 0.836; p = 0.016). In patients undergoing SPCI later than 10 days after index procedure, this risk reduction was still prominent (0.8% vs 23%; HR 0.321; 95% CI 0.116 to 0.891; p = 0.029). In conclusion, patients undergoing SPCI are at high risk and may need special attention from clinicians. In ACS patients undergoing SPCI, a novel aspirin-free anti-platelet regimen appears to be associated with a lower bleeding risk than with standard DAPT. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | The Global Leaders study was sponsored by the European Clinical Research Institute, which received funding from AstraZeneca, Biosensors International and the Medicines Company. The study funders had no role in trial design, data collection, analysis, interpretation of the data, preparation, approval or making decision to submit the manuscript or publication. | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.rights | 2020 Elsevier Inc. All rights reserved | - |
dc.subject.other | Acute Coronary Syndrome | - |
dc.subject.other | Aged | - |
dc.subject.other | Aspirin | - |
dc.subject.other | Coronary Stenosis | - |
dc.subject.other | Drug-Eluting Stents | - |
dc.subject.other | Dual Anti-Platelet Therapy | - |
dc.subject.other | Female | - |
dc.subject.other | Hemorrhage | - |
dc.subject.other | Humans | - |
dc.subject.other | Male | - |
dc.subject.other | Middle Aged | - |
dc.subject.other | Myocardial Infarction | - |
dc.subject.other | Percutaneous Coronary Intervention | - |
dc.subject.other | Platelet Aggregation Inhibitors | - |
dc.subject.other | Ticagrelor | - |
dc.subject.other | Treatment Outcome | - |
dc.subject.other | Mortality | - |
dc.title | Safety and Efficacy of 1-Month Dual Antiplatelet Therapy (Ticagrelor + Aspirin) Followed by 23-Month Ticagrelor Monotherapy in Patients Undergoing Staged Percutaneous Coronary Intervention (A Sub-Study from GLOBAL LEADERS) | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 10 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 138 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Serruys, PW (corresponding author), Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.; Serruys, PW (corresponding author), Imperial Coll London, NHLI, London, England. | - |
dc.description.notes | patrick.w.j.c.serruys@gmail.com | - |
dc.description.other | Serruys, PW (corresponding author), Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland. Imperial Coll London, NHLI, London, England. patrick.w.j.c.serruys@gmail.com | - |
local.publisher.place | 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.amjcard.2020.09.057 | - |
dc.identifier.pmid | 33065080 | - |
dc.identifier.isi | WOS:000600836900001 | - |
dc.contributor.orcid | Gao, Chao/0000-0002-0390-8060 | - |
dc.identifier.eissn | 1879-1913 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Kawashima, Hideyuki; Ono, Masafumi; Hara, Hironori; Takahashi, Kuniaki; Wykrzykowska, Joanna; de Winter, Robbert J.] Univ Amsterdam, Heart Ctr, Amsterdam UMC, Amsterdam, Netherlands. | - |
local.description.affiliation | [Kawashima, Hideyuki; Ono, Masafumi; Hara, Hironori; Takahashi, Kuniaki; Wykrzykowska, Joanna; de Winter, Robbert J.] Amsterdam Cardiovasc Sci, Dept Clin & Expt Cardiol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Kawashima, Hideyuki; Ono, Masafumi; Wang, Rutao; Gao, Chao; Sharif, Faisal; Onuma, Yoshinobu; Serruys, Patrick W.] Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland. | - |
local.description.affiliation | [Tomaniak, Mariusz] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland. | - |
local.description.affiliation | [Wang, Rutao; Gao, Chao; Suryapranata, Harry] Radboud Univ Nijmegen, Dept Cardiol, Med Ctr, Nijmegen, Netherlands. | - |
local.description.affiliation | [Thury, Attila] Univ Szeged, Cardiol Ctr, Szeged, Hungary. | - |
local.description.affiliation | [Walsh, Simon] Belfast Hlth & Social Care Trust, Dept Cardiol, Belfast, Antrim, North Ireland. | - |
local.description.affiliation | [Cotton, James] New Cross Hosp, Heart & Lung Ctr, Wolverhampton, England. | - |
local.description.affiliation | [Carrie, Didier] Paul Sabatier Univ Toulouse 3, Rangueil Hosp, Dept Cardiol, Toulouse, France. | - |
local.description.affiliation | [Sabate, Manel] Clin Hosp Barcelona, Barcelona, Spain. | - |
local.description.affiliation | [Steinwender, Clemens] Johannes Kepler Univ Linz, Kepler Univ Hosp, Linz Med Fac, Dept Cardiol, Linz, Austria. | - |
local.description.affiliation | [Leibundgut, Gregor] Kantonsspital Baselland, Dept Cardiol, Liestal, Switzerland. | - |
local.description.affiliation | [Garg, Scot] Royal Blackburn Hosp, Blackburn, Lancs, England. | - |
local.description.affiliation | [Hamm, Christian] Campus Univ Giessen, Kerckhoff Heart Ctr, Bad Nauheim, Germany. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Univ Paris Diderot, Hop Bichat, AP HP, FACT French Alliance Cardiovasc Trials,INSERM U 1, Paris, France. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Royal Brompton Hosp, Imperial Coll, Natl Heart & Lung Inst, London, England. | - |
local.description.affiliation | [Juni, Peter] Univ Toronto, Appl Hlth Res Ctr, Li Ka Shing Knowledge Inst, Dept Med,St Michaels Hosp, Toronto, ON, Canada. | - |
local.description.affiliation | [Juni, Peter] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada. | - |
local.description.affiliation | [Vranckx, Pascal] Hasselt Univ, Fac Med & Life Sci, Jessa Ziekenhuis, Hasselt, Belgium. | - |
local.description.affiliation | [Valgimigli, Marco; Windecker, Stephan] Univ Bern, Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland. | - |
local.description.affiliation | [Serruys, Patrick W.] Imperial Coll London, NHLI, London, England. | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.contributor | Kawashima, Hideyuki | - |
item.contributor | Tomaniak, Mariusz | - |
item.contributor | Ono, Masafumi | - |
item.contributor | Wang, Rutao | - |
item.contributor | Hara, Hironori | - |
item.contributor | Gao, Chao | - |
item.contributor | Takahashi, Kuniaki | - |
item.contributor | Sharif, Faisal | - |
item.contributor | Thury, Attila | - |
item.contributor | Suryapranata, Harry | - |
item.contributor | Walsh, Simon | - |
item.contributor | Cotton, James | - |
item.contributor | Carrie, Didier | - |
item.contributor | Sabate, Manel | - |
item.contributor | Steinwender, Clemens | - |
item.contributor | Leibundgut, Gregor | - |
item.contributor | Wykrzykowska, Joanna | - |
item.contributor | de Winter, Robbert J. | - |
item.contributor | Garg, Scot | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Juni, Peter | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | Serruys, Patrick W. | - |
item.fullcitation | Kawashima, Hideyuki; Tomaniak, Mariusz; Ono, Masafumi; Wang, Rutao; Hara, Hironori; Gao, Chao; Takahashi, Kuniaki; Sharif, Faisal; Thury, Attila; Suryapranata, Harry; Walsh, Simon; Cotton, James; Carrie, Didier; Sabate, Manel; Steinwender, Clemens; Leibundgut, Gregor; Wykrzykowska, Joanna; de Winter, Robbert J.; Garg, Scot; Hamm, Christian; Steg, Philippe Gabriel; Juni, Peter; VRANCKX, Pascal; Valgimigli, Marco; Windecker, Stephan; Onuma, Yoshinobu & Serruys, Patrick W. (2021) Safety and Efficacy of 1-Month Dual Antiplatelet Therapy (Ticagrelor + Aspirin) Followed by 23-Month Ticagrelor Monotherapy in Patients Undergoing Staged Percutaneous Coronary Intervention (A Sub-Study from GLOBAL LEADERS). In: The American journal of cardiology, 138 , p. 1 -10. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 0002-9149 | - |
crisitem.journal.eissn | 1879-1913 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0002914920310882-main.pdf Restricted Access | Published version | 1.65 MB | Adobe PDF | View/Open Request a copy |
Manuscript_staged PCI.pdf | Peer-reviewed author version | 1.79 MB | Adobe PDF | View/Open |
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