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Title: | Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements e A neuro-navigated rTMS study | Authors: | VERSTRAELEN, Stefanie Nitsche, Michael VAN DUN, Kim DEPESTELE, Siel VAN HOORNWEDER, Sybren JAMIL, Asif GHASEMIAN SHIRVAN, Ensiyeh Swinnen, Stephan VAN MALDEREN, Shanti CUYPERS, Koen MEESEN, Raf |
Issue Date: | 2021 | Publisher: | ELSEVIER SCIENCE INC | Source: | Brain Stimulation, 14 (2) , p. 423 -434 | Abstract: | Background: The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking. Objective: We investigated how left (PMd L) and right PMd (PMd R) are causally involved in planning and executing bimanual movements, using short-train repetitive transcranial magnetic stimulation (rTMS). Additionally, we explored to what extent the observed rTMS-induced modulation of performance could be explained by rTMS-induced modulation of PMd-M1 interhemispheric interactions (IHI). Methods: Twenty healthy adults (mean age ± SD = 22.85 ± 3.73 years) participated in two sessions, in which either PMd L or PMd R was targeted with rTMS (10 Hz) in a pseudo-randomized design. PMd functionality was transiently modulated during the planning or execution of a complex bimanual task, whereby the participant was asked to track a moving dot by controlling two dials. The effect of rTMS on several performance measures was investigated. Concurrently, rTMS-induced modulation of PMd-M1 IHI was measured using a dual-coil paradigm, and associated with the rTMS-induced performance modulation. Results: rTMS over PMd L during planning increased bilateral hand movement speed (p = 0.03), thereby improving movement accuracy (p = 0.02). In contrast, rTMS over PMd R during both planning and execution induced deterioration of movement stability (p = 0.04). rTMS-induced modulation of PMd-M1 IHI during planning did not predict rTMS-induced performance modulation. Conclusion: The current findings support the growing evidence on PMd L dominance during motor planning, as PMd L was crucially involved in planning the speed of each hand, subserving bimanual coordination accuracy. Moreover, the current results suggest that PMd R fulfills a role in continuous adjustment processes of movement. | Keywords: | Bimanual coordination;Dorsal premotor cortex;Repetitive transcranial magnetic stimulation;Interhemispheric interaction;Virtual lesion | Document URI: | http://hdl.handle.net/1942/33628 | ISSN: | 1935-861X | e-ISSN: | 1876-4754 | DOI: | 10.1016/j.brs.2021.02.006 | ISI #: | WOS:000632697000033 | Rights: | 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Verstraelen et al. 2021.pdf | Published version | 1.66 MB | Adobe PDF | View/Open |
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