Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33628
Title: Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements e A neuro-navigated rTMS study
Authors: VERSTRAELEN, Stefanie 
Nitsche, Michael
VAN DUN, Kim 
DEPESTELE, Siel 
VAN HOORNWEDER, Sybren 
JAMIL, Asif 
GHASEMIAN SHIRVAN, Ensiyeh 
Swinnen, Stephan
VAN MALDEREN, Shanti 
CUYPERS, Koen 
MEESEN, Raf 
Issue Date: 2021
Publisher: ELSEVIER SCIENCE INC
Source: Brain Stimulation, 14 (2) , p. 423 -434
Abstract: Background: The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking. Objective: We investigated how left (PMd L) and right PMd (PMd R) are causally involved in planning and executing bimanual movements, using short-train repetitive transcranial magnetic stimulation (rTMS). Additionally, we explored to what extent the observed rTMS-induced modulation of performance could be explained by rTMS-induced modulation of PMd-M1 interhemispheric interactions (IHI). Methods: Twenty healthy adults (mean age ± SD = 22.85 ± 3.73 years) participated in two sessions, in which either PMd L or PMd R was targeted with rTMS (10 Hz) in a pseudo-randomized design. PMd functionality was transiently modulated during the planning or execution of a complex bimanual task, whereby the participant was asked to track a moving dot by controlling two dials. The effect of rTMS on several performance measures was investigated. Concurrently, rTMS-induced modulation of PMd-M1 IHI was measured using a dual-coil paradigm, and associated with the rTMS-induced performance modulation. Results: rTMS over PMd L during planning increased bilateral hand movement speed (p = 0.03), thereby improving movement accuracy (p = 0.02). In contrast, rTMS over PMd R during both planning and execution induced deterioration of movement stability (p = 0.04). rTMS-induced modulation of PMd-M1 IHI during planning did not predict rTMS-induced performance modulation. Conclusion: The current findings support the growing evidence on PMd L dominance during motor planning, as PMd L was crucially involved in planning the speed of each hand, subserving bimanual coordination accuracy. Moreover, the current results suggest that PMd R fulfills a role in continuous adjustment processes of movement.
Keywords: Bimanual coordination;Dorsal premotor cortex;Repetitive transcranial magnetic stimulation;Interhemispheric interaction;Virtual lesion
Document URI: http://hdl.handle.net/1942/33628
ISSN: 1935-861X
e-ISSN: 1876-4754
DOI: 10.1016/j.brs.2021.02.006
ISI #: WOS:000632697000033
Rights: 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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