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Title: | Measurement of Biomimetic Deposition of Calcium Phosphate in Real Time Using Complex Capacitance | Authors: | Guttenplan, Alexander P. M. BORMANS, Seppe Birgani, Zeinab Tahmasebi Schumacher, Matthias Giselbrecht, Stefan Truckenmuller, Roman K. Habibovic, Pamela THOELEN, Ronald |
Issue Date: | 2021 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | Physica status solidi (A), 218(13), (Art N° 2000672) | Abstract: | Deposition of minerals, particularly calcium phosphates such as hydroxyapatite, is an important process in the formation of hard tissues such as bone. Herein, a new, affordable, straightforward and nondestructive method based on complex capacitance spectroscopy, an application of electrochemical impedance spectroscopy, is described which allows repeated and real-time measurements of the same sample throughout the calcium phosphate deposition process. In contrast with end-point assays which require large numbers of samples to obtain useful time-course data, this method allows the kinetics of deposition to be measured using a single sample by measuring the impedance of a pair of interdigitated electrodes at a range of frequencies as the layer of mineral is deposited. Changes in the complex capacitance curve over time with deposition can be compared with images of the coating deposited on model substrates, and show different behavior depending on the composition of the coating and the conditions of deposition. | Notes: | Habibovic, P (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Instruct Biomat Engn, Univ Singel 40, NL-6229 ER Maastricht, Netherlands.; Thoelen, R (corresponding author), Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1, B-3590 Diepenbeek, Belgium.; Thoelen, R (corresponding author), IMEC VZW, IMOMEC Div, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. p.habibovic@maastrichtuniversity.nl; ronald.thoelen@uhasselt.be |
Other: | Habibovic, P (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Instruct Biomat Engn, Univ Singel 40, NL-6229 ER Maastricht, Netherlands. Thoelen, R (corresponding author), Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1, B-3590 Diepenbeek, Belgium ; IMEC VZW, IMOMEC Div, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. p.habibovic@maastrichtuniversity.nl; ronald.thoelen@uhasselt.be | Keywords: | calcium phosphate;complex capacitance spectroscopy;electrical impedance;sensors | Document URI: | http://hdl.handle.net/1942/33717 | ISSN: | 1862-6300 | e-ISSN: | 1862-6319 | DOI: | 10.1002/pssa.202000672 | ISI #: | WOS:000618374000001 | Rights: | 2021 The Authors. physica status solidi (a) applications and materials science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Physica Status Solidi a - 2021 - Guttenplan - Measurement of Biomimetic Deposition of Calcium Phosphate in Real Time Using.pdf | Published version | 1.52 MB | Adobe PDF | View/Open |
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