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http://hdl.handle.net/1942/3375
Title: | Causal inference in a placebo-controlled clinical trial with binary outcome and ordered compliance | Authors: | GOETGHEBEUR, Els MOLENBERGHS, Geert |
Issue Date: | 1996 | Publisher: | AMER STATIST ASSN | Source: | JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 91(435). p. 928-934 | Abstract: | We propose a likelihood-based method to analyze the causal effect of partial compliance (i.e., unplanned partial exposure to treatment or placebo) in the LRC-CPPT data, a prevention trial with long term follow-up previously analyzed by Efron and Feldman. Initially, we construct ordered compliance categories and dichotomize response. Assuming increased exposure to cholestyramine does not increase cholesterol, we estimate exposure-response curves in different compliance subsets. Subjects in different arms with similar levels of compliance to the assignment may have a different placebo prognosis (i.e., success probability under a possible zero exposure level). The sole assumption that the placebo group reflects response to zero exposure for the treatment group as a whole allows estimation of a causal parameter in a special case only. When a single parameter represents the association between responses to possible treatment exposures and treatment compliance, simple estimates are derived for a set of causal parameters. The example is analyzed in detail, and more general applicability and extensions of the method are discussed. | Notes: | LIMBURGS UNIV CTR,BIOSTAT RES UNIT,B-3590 DIEPENBEEK,BELGIUM.Goetghebeur, E, UNIV LIMBURG,METHODOL & STAT UNIT,PB 616,NL-6200 MD MAASTRICHT,NETHERLANDS. | Keywords: | coarsening; counterfactual framework; efficacy; intention to treat; interval censoring; ordinal data;coarsening; counterfactual framework; efficacy; intention to treat; interval censoring; ordinal data | Document URI: | http://hdl.handle.net/1942/3375 | ISSN: | 0162-1459 | e-ISSN: | 1537-274X | DOI: | 10.2307/2291711 | ISI #: | A1996VK23300002 | Rights: | (C) 1996 American Statistical Association | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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goetghebeur1996.pdf Restricted Access | Published version | 1.46 MB | Adobe PDF | View/Open Request a copy |
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