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Title: | Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John’s wort’s (Hypericum perforatum L.) flowers | Authors: | Makarova, Katerina Sajkowska-Kozielewicz, Joanna J. Zawada, Katarzyna Olchowik-Grabarek, Ewa CIACH, Michal Gogolewski, Krzysztof Dobros, Natalia Ciechowicz, Paulina Freichels, Helene Gambin, Anna |
Issue Date: | 2021 | Publisher: | NATURE RESEARCH | Source: | Scientific reports, 11 (1) (Art N° 3989) | Abstract: | The polyphenol content and antioxidant capacity of hyperforin and hypericin-standardized H. perforatum L. extracts may vary due to the harvest time. In this work, ethanol and ethanol-water extracts of air-dried and lyophilized flowers of H. perforatum L., collected throughout a vegetation season in central Poland, were studied. Air-dried flowers extracts had higher polyphenol (371 mg GAE/g) and flavonoid (160 mg CAE/g) content, DPPH radical scavenging (1672 mg DPPH/g), ORAC (5214 mu mol TE/g) and FRAP (2.54 mmol Fe2+/g) than lyophilized flowers extracts (238 mg GAE/g, 107 mg CAE/g, 1287 mg DPPH/g, 3313 mu mol TE/g and 0.31 mmol Fe2+/g, respectively). Principal component analysis showed that the collection date influenced the flavonoid and polyphenol contents and FRAP of ethanol extracts, and DPPH and ORAC values of ethanol-water extracts. The ethanol extracts with the highest polyphenol and flavonoid content protected human erythrocytes against bisphenol A-induced damage. Both high field and benchtop NMR spectra of selected extracts, revealed differences in composition caused by extraction solvent and raw material collection date. Moreover, we have shown that benchtop NMR can be used to detect the compositional variation of extracts if the assignment of signals is done previously. | Notes: | Makarova, K (corresponding author), Med Univ Warsaw, Dept Phys Chem, Chair Phys Pharm & Bioanal, Fac Pharm,Lab Med Div, Banacha 1, PL-02097 Warsaw, Poland. Katerina.makarova@gmail.com |
Other: | Makarova, K (corresponding author), Med Univ Warsaw, Dept Phys Chem, Chair Phys Pharm & Bioanal, Fac Pharm,Lab Med Div, Banacha 1, PL-02097 Warsaw, Poland. Katerina.makarova@gmail.com | Keywords: | Anthracenes;Antioxidants;Benzhydryl Compounds;Ethanol;Flavonoids;Flowers;Humans;Hypericum;Perylene;Phenols;Phloroglucinol;Plant Extracts;Poland;Polyphenols;Principal Component Analysis;Terpenes | Document URI: | http://hdl.handle.net/1942/33897 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-83409-4 | ISI #: | WOS:000621344600014 | Rights: | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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s41598-021-83409-4.pdf | Published version | 1.56 MB | Adobe PDF | View/Open |
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