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http://hdl.handle.net/1942/34287| Title: | A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes | Authors: | PENG, Qiyao VERMOLEN, Fred Weihs, D |
Corporate Authors: | Qiyao Peng, Daphne Weihs, Fred Vermolen | Issue Date: | 2021 | Publisher: | Source: | Biomechanics and Modeling in Mechanobiology, 20(4), p. 1459-1475 | Abstract: | The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429-1450, 2018), Vermolen and Gefen (BMM 12:301-323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340-348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework. | Keywords: | Cell geometry;Cell migration;Cellular traction forces;Finite-element method;Agent-based modelling | Document URI: | http://hdl.handle.net/1942/34287 | ISSN: | 1617-7959 | e-ISSN: | 1617-7940 | DOI: | 10.1007/s10237-021-01456-2 | ISI #: | WOS:000642846400001 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
| Appears in Collections: | Research publications |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| s10237-021-01456-2.pdf | Published version | 3.91 MB | Adobe PDF | View/Open |
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