Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/34517
Title: | Evaluation of an osteochondral fragment–groove procedure for induction of metacarpophalangeal joint osteoarthritis in horses | Authors: | Broeckx, Sarah Y. Pille, Frederik Buntinx, Simon Van Brantegem, Leen DUCHATEAU, Luc Oosterlinck, Maarten Chiers, Koen Bertone, Alicia L. SPAAS, Jan Martens, Ann M. |
Issue Date: | 2019 | Publisher: | Source: | AMERICAN JOURNAL OF VETERINARY RESEARCH, 80 (3) , p. 246 -258 | Abstract: | OBJECTIVE To evaluate lameness and morphological changes associated with an osteochondral fragment-groove procedure as a means of experimental induction of metacarpophalangeal (MCP) joint osteoarthritis within an 11-week period in horses. ANIMALS 6 nonlame adult warmbloods. PROCEDURES The right MCP joint of each horse underwent an osteochondral fragment-groove procedure (day 0). After 1 week of stall rest (ie, starting day 7), each horse was trained daily on a treadmill. Weekly, horses underwent visual and inertial sensor-based assessments of lameness. Both MCP joints were assessed radiographically on days 0 (before surgery), 1, 35, and 77. A synovial fluid sample was collected from the right MCP joint on days 0 (before surgery), 35, 36, 49, 63, and 77 for cytologic and biomarker analyses. On day 77, each horse was euthanized; both MCP joints were evaluated macroscopically and histologically. RESULTS Right forelimb lameness was detected visually and by the inertial sensor system when horses were moving on a straight line after distal forelimb flexion or circling left on days 14 to 77. Compared with presurgical values, synovial fluid interleukin-6, prostaglandin E2, hyaluronic acid, and interleukin-1 receptor antagonist protein concentrations were increased at 2 or 3 time points, whereas tumor necrosis factor-alpha and interleukin-10 concentrations were decreased at 1 time point. Gross examination of all right MCP joints revealed synovitis and wear lines; synovitis was confirmed histologically. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that a combined osteochondral fragment-groove procedure can be used to induce clinically and grossly observable early MCP joint osteoarthritis during an 11-week period in horses. | Document URI: | http://hdl.handle.net/1942/34517 | ISSN: | 0002-9645 | e-ISSN: | 1943-5681 | DOI: | 10.2460/ajvr.80.3.246 | ISI #: | WOS:000459540600014 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Show full item record
WEB OF SCIENCETM
Citations
10
checked on Apr 30, 2024
Page view(s)
42
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.