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http://hdl.handle.net/1942/34571
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DC Field | Value | Language |
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dc.contributor.author | Catala, Gaetan | - |
dc.contributor.author | MEBIS, Jeroen | - |
dc.contributor.author | Jerusalem, Guy | - |
dc.contributor.author | Verhoeven, Didier | - |
dc.contributor.author | Awada, Ahmad | - |
dc.contributor.author | Bols, Alain | - |
dc.contributor.author | Somers, Luc | - |
dc.contributor.author | Van Den Broeck, Anke | - |
dc.contributor.author | Duhoux, Francois P | - |
dc.contributor.author | Machiels, Jean-Pascal | - |
dc.date.accessioned | 2021-07-26T14:59:23Z | - |
dc.date.available | 2021-07-26T14:59:23Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-07-09T13:59:17Z | - |
dc.identifier.citation | Acta clinica belgica (English ed. Printed), 75 (2) , p. 128 -135 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34571 | - |
dc.description.abstract | Background: Chemotherapy plays an important role in the treatment of early breast cancer (EBC). Granulocyte-colony stimulating factors (G-CSF) can reduce the risk of febrile neutropenia as primary prophylaxis (PP) or secondary prophylaxis (SP). The BRONS study investigated the incidence of serious neutropenic events (SNE) and G-CSF use in a Belgian population of EBC patients treated with myelosuppressive polychemotherapy. Methods: Conducted in 2011, this study was a prospective, multicentre, observational trial involving 260 patients. The primary endpoint was the incidence of SNE defined as either febrile neutropenia (FN) or prolonged severe neutropenia (PSN; neutrophil count <= 0.5 x 10x2079; for at least five days). Secondary endpoints included a description of the chemotherapeutic regimens prescribed and G-CSF use. Results: Nine percent of patients were treated with a dose-dense regimen (DD) and 91% received classical chemotherapy (CC). PP with G-CSF (PPG) was given to 20% of patients (100% in DD and 11% in CC). Eighteen percent of patients presented a SNE (4% in DD and 20% in CC) of which 15% were FN and 3% PSN. SNE occurrence was 8% in the PPG subgroup and 21% in the no-PPG subgroup. In the DD subgroup, all patients received PPG and no FN was reported. Twenty six adverse events related to G-CSF were reported in 8.2% of patients and two of these were classified as severe. Conclusion: This observational study highlights the high incidence of SNE with CC regimens in patients who do not receive PPG. It also confirms the safe profile of DD regimens with G-CSF support. | - |
dc.language.iso | en | - |
dc.title | Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 135 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 128 | - |
dc.identifier.volume | 75 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1080/17843286.2018.1563735 | - |
dc.identifier.isi | WOS:000515530700007 | - |
dc.contributor.orcid | Catala, Gaetan/0000-0003-2483-4977; Duhoux, Francois/0000-0002-5429-7888 | - |
local.provider.type | wosris | - |
local.uhasselt.international | no | - |
item.fullcitation | Catala, Gaetan; MEBIS, Jeroen; Jerusalem, Guy; Verhoeven, Didier; Awada, Ahmad; Bols, Alain; Somers, Luc; Van Den Broeck, Anke; Duhoux, Francois P & Machiels, Jean-Pascal (2020) Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results. In: Acta clinica belgica (English ed. Printed), 75 (2) , p. 128 -135. | - |
item.contributor | Catala, Gaetan | - |
item.contributor | MEBIS, Jeroen | - |
item.contributor | Jerusalem, Guy | - |
item.contributor | Verhoeven, Didier | - |
item.contributor | Awada, Ahmad | - |
item.contributor | Bols, Alain | - |
item.contributor | Somers, Luc | - |
item.contributor | Van Den Broeck, Anke | - |
item.contributor | Duhoux, Francois P | - |
item.contributor | Machiels, Jean-Pascal | - |
item.accessRights | Closed Access | - |
item.fulltext | No Fulltext | - |
crisitem.journal.issn | 1784-3286 | - |
crisitem.journal.eissn | 2295-3337 | - |
Appears in Collections: | Research publications |
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