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Title: | Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results | Authors: | Catala, Gaetan MEBIS, Jeroen Jerusalem, Guy Verhoeven, Didier Awada, Ahmad Bols, Alain Somers, Luc Van Den Broeck, Anke Duhoux, Francois P Machiels, Jean-Pascal |
Issue Date: | 2020 | Source: | Acta clinica belgica (English ed. Printed), 75 (2) , p. 128 -135 | Abstract: | Background: Chemotherapy plays an important role in the treatment of early breast cancer (EBC). Granulocyte-colony stimulating factors (G-CSF) can reduce the risk of febrile neutropenia as primary prophylaxis (PP) or secondary prophylaxis (SP). The BRONS study investigated the incidence of serious neutropenic events (SNE) and G-CSF use in a Belgian population of EBC patients treated with myelosuppressive polychemotherapy. Methods: Conducted in 2011, this study was a prospective, multicentre, observational trial involving 260 patients. The primary endpoint was the incidence of SNE defined as either febrile neutropenia (FN) or prolonged severe neutropenia (PSN; neutrophil count <= 0.5 x 10x2079; for at least five days). Secondary endpoints included a description of the chemotherapeutic regimens prescribed and G-CSF use. Results: Nine percent of patients were treated with a dose-dense regimen (DD) and 91% received classical chemotherapy (CC). PP with G-CSF (PPG) was given to 20% of patients (100% in DD and 11% in CC). Eighteen percent of patients presented a SNE (4% in DD and 20% in CC) of which 15% were FN and 3% PSN. SNE occurrence was 8% in the PPG subgroup and 21% in the no-PPG subgroup. In the DD subgroup, all patients received PPG and no FN was reported. Twenty six adverse events related to G-CSF were reported in 8.2% of patients and two of these were classified as severe. Conclusion: This observational study highlights the high incidence of SNE with CC regimens in patients who do not receive PPG. It also confirms the safe profile of DD regimens with G-CSF support. | Document URI: | http://hdl.handle.net/1942/34571 | ISSN: | 1784-3286 | e-ISSN: | 2295-3337 | DOI: | 10.1080/17843286.2018.1563735 | ISI #: | WOS:000515530700007 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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