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Title: | Association of Pulse Pressure With Clinical Outcomes in Patients Under Different Antiplatelet Strategies After Percutaneous Coronary Intervention: Analysis of GLOBAL LEADERS | Authors: | de Faria, Ana Paula Modolo, Rodrigo Chichareon, Ply Chang, Chun-Chin Kogame, Norihiro Tomaniak, Mariusz Takahashi, Kuniaki Rademaker-Havinga, Tessa Wykrzykowska, Joanna de Winter, Rob J. Ferreira, Rui C. Sousa, Amanda Lemos, Pedro A. Garg, Scot Hamm, Christian Juni, Peter VRANCKX, Pascal Valgimigli, Marco Windecker, Stephan Onuma, Yoshinobu Steg, Philippe Gabriel Serruys, Patrick W. |
Issue Date: | 2020 | Source: | Canadian journal of cardiology (Print) = Journal canadienne de cardiologie, 36 (5) , p. 747 -755 | Abstract: | Background: We evaluated the association of pulse pressure (PP) and different antiplatelet regimes with clinical and safety outcomes in an all-comers percutaneous coronary intervention (PCI) population. Methods: In this analysis of GLOBAL LEADERS (n = 15,936) we compared the experimental therapy of 23 months of ticagrelor after 1 month of dual-antiplatelet therapy (DAPT) vs standard DAPT for 12 months followed by aspirin monotherapy in subjects who underwent PCI and were divided into 2 groups according to the median PP (60 mm Hg). The primary end point (all-cause death or new Q-wave myocardial infarction) and the composite end points: patient-oriented composite end points (POCE), Bleeding Academic Research Consortium (BARC) 3 or 5, and net adverse clinical events (NACE) were evaluated. Results: At 2 years, subjects in the high-PP group (n = 7971) had similar rates of the primary end point (4.3% vs 3.9%; P = 0.058), POCE (14.9% vs 12.7%; P = 0.051), and BARC 3 or 5 (2.5% vs 1.7%; P = 0.355) and higher rates of NACE (16.4% vs 13.7%; P = 0.037) compared with the low-PP group (n = 7965). Among patients with PP < 60 mm Hg, the primary end point (3.4% vs 4.4%, adjusted hazard ratio [aHR] 0.77, 95% confidence interval [CI] 0.61-0.96), POCE (11.8% vs 13.5%, aHR 0.86, 95% | Document URI: | http://hdl.handle.net/1942/34599 | ISSN: | 0828-282X | e-ISSN: | 1916-7075 | DOI: | 10.1016/j.cjca.2019.10.015 | ISI #: | WOS:000532690200016 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S0828282X19313509-main.pdf Restricted Access | Published version | 1.14 MB | Adobe PDF | View/Open Request a copy |
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