Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34738
Title: Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017: data collection, management and analysis
Authors: BRUYNDONCKX, Robin 
Adriaenssens, Niels
Versporten, Ann
HENS, Niel 
Monnet, Dominique L.
MOLENBERGHS, Geert 
Goossens, Herman
Weist, Klaus
Coenen, Samuel
Issue Date: 2021
Publisher: OXFORD UNIV PRESS
Source: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76 (Supplement_2) , p. 2 -6
Abstract: Objectives: This article introduces a series of articles on antibiotic consumption in the community between 1997 and 2017, which provide an update of previous articles covering the periods 1997-2003 and 1997-2009. Methods: In this article, differences in participating countries, the ATC/DDD classification system, and data collection, validation and analysis between the current and previous series are described. Results: In the previous series, 33 European countries provided valid data for further analysis, while the current series focused on 30 countries belonging to the EU or the European Economic Area (EEA). For both series, data were collected in accordance with the WHO ATC classification system. While the previous series reported data in accordance with the ATC/DDD index 2011, the current series employed the ATC/DDD index 2019. Both series focused on consumption of antibacterials for systemic use (ATC J01) and collected data expressed in DDD per 1000 inhabitants per day and packages per 1000 inhabitants per day. When studying consumption expressed in packages per 1000 inhabitants per day, countries reporting total care data, i.e. community and hospital sector combined, were included in the previous series but excluded in the current series. While the previous series used non-linear mixed models to evaluate time trends in antibiotic consumption, the current series allowed for inclusion of change-points with a data-driven location. In addition, both series assessed the composition and quality of antibiotic consumption in the EU/EEA. Conclusions: The updated analyses of two decades of ESAC-Net data provide the most comprehensive and detailed description of antibiotic consumption in the community in Europe.
Notes: Bruyndonckx, R (corresponding author), Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium.; Bruyndonckx, R (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Data Sci Inst, Hasselt, Belgium.
robin.bruyndonckx@uhasselt.be
Keywords: Cardiac lipoma;Radical resection;Minimally invasive;Clinical management;Case report
Document URI: http://hdl.handle.net/1942/34738
ISSN: 0305-7453
e-ISSN: 1460-2091
DOI: 10.1093/jac/dkab171
ISI #: WOS:000684146500002
Rights: VC The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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