Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34739
Title: Quality appraisal of antibiotic consumption in the community, European Union/European Economic Area, 2009 and 2017
Authors: Adriaenssens, Niels
BRUYNDONCKX, Robin 
Versporten, Ann
HENS, Niel 
Monnet, Dominique L.
MOLENBERGHS, Geert 
Goossens, Herman
Weist, Klaus
Coenen, Samuel
Issue Date: 2021
Publisher: OXFORD UNIV PRESS
Source: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76 (Supplement_2) , p. 60 -67
Abstract: Objectives: The quality of antibiotic consumption in the community can be assessed using 12 drug-specific quality indicators (DSQIs) developed by the European Surveillance of Antimicrobial Consumption (ESAC) project. We compared quality in 2009 and 2017 in the EU/European Economic Area (EEA) and evaluated the impact of using different DDD values (ATC/DDD indices 2011 and 2019) for the 2009 quality assessment using these DSQIs and a joint scientific opinion (JSO) indicator. Methods: We calculated the 12 DSQIs and the JSO indicator for 2017 and for 2009 for EU/EEA countries able to deliver values. For each of the indicators we grouped the 2017 and 2009 indicator values into four quartiles. To evaluate changes in quality between 2009 and 2017, we used the quartile distribution of the 2009 indicator values in 30 EU/EEA countries as benchmarks. In addition, we compared the quality assessment for 2009 using the ATC/DDD indices 2011 and 2019. Results: In 2017, a difference in the quality of antibiotic consumption in the community between northern and southern EU/EEA countries remained, but also several eastern EU/EEA countries shifted towards lower quality. Quality of antibiotic consumption decreased between 2009 and 2017 in particular indicator values for penicillin, quinolone, relative beta-lactam and broad- versus narrow-spectrum antibiotic consumption, and seasonal variation. Using different ATC/DDD indices did not substantially change countries' ranking based on their DSQI values. Conclusions: The quality of antibiotic consumption in the community as measured by the DSQIs further decreased between 2009 and 2017, especially in Southern and Eastern European countries. A continuous effort to improve antibiotic consumption is essential to reduce antibiotic consumption in general and the use of broad-spectrum antibiotics in particular.
Notes: Adriaenssens, N (corresponding author), Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium.; Adriaenssens, N (corresponding author), Univ Antwerp, Ctr Gen Practice, Dept Family Med & Populat Hlth FAMPOP, Antwerp, Belgium.
niels.adriaenssens@uantwerpen.be
Document URI: http://hdl.handle.net/1942/34739
ISSN: 0305-7453
e-ISSN: 1460-2091
DOI: 10.1093/jac/dkab178
ISI #: WOS:000684146500009
Rights: VC The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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