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Title: | Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project | Authors: | Bauckneht, Matteo Chincarini, Andrea Brendel, Matthias Rominger, Axel BRUFFAERTS, Rose Vandenberghe, Rik Kramberger, Milica G. Trost, Maja Garibotto, Valentina Nicastro, Nicolas Frisoni, Giovanni B. Lemstra, Afina W. Berckel, Bart N. M. Pilotto, Andrea Padovani, Alessandro Ochoa-Figueroa, Miguel A. Davidsson, Anette Camacho, Valle Peira, Enrico Arnaldi, Dario Pardini, Matteo Donegani, Maria Isabella Raffa, Stefano Miceli, Alberto Sambuceti, Gianmario Aarsland, Dag Nobili, Flavio Morbelli, Silvia Beyer, Leonie |
Issue Date: | 2021 | Publisher: | WILEY | Source: | Alzheimer's & dementia, 17 (8) , p. 1277 -1286 | Abstract: | Introduction We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve. | Notes: | Morbelli, S (corresponding author), Univ Genoa, Dept Hlth Sci DISSAL, IRCCS Osped Policlin San Martino, Nucl Med Unit, Largo R Benzi 10, I-16132 Genoa, Italy. silvia.morbelli@unige.it |
Keywords: | biomarkers;cognitive reserve;dementia with Lewy bodies;fluorodeoxyglucose positron emission tomography | Document URI: | http://hdl.handle.net/1942/34791 | ISSN: | 1552-5260 | e-ISSN: | 1552-5279 | DOI: | 10.1002/alz.12294 | ISI #: | WOS:000685986400002 | Rights: | 2021 the Alzheimer’s Association | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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