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Title: | Efficient long-range conduction in cable bacteria through nickel protein wires | Authors: | Boschker, HTS Cook, PLM Polerecky, L THIRUVALLUR EACHAMBADI, Ragha Lozano, H Hidalgo-Martinez, S Khalenkow, D Spampinato, V Claes , N Kundu, P Wang, D Bals, S Sand, KK Cavezza, F Hauffman, T Bjerg, JT Skirtach, AG Kochan, K McKee, M Wood, B Bedolla, D Gianoncelli, A Geerlings, NMJ Van Gerven, N Remaut, H Geelhoed, JS Millan-Solsona, R Fumagalli, L Nielsen, LP Franquet, A MANCA, Jean Gomila, G Meysman, FJR |
Issue Date: | 2021 | Publisher: | NATURE RESEARCH | Source: | Nature communications, 12 (1) (Art N° 3996) | Abstract: | Filamentous cable bacteria display long-range electron transport, generating electrical currents over centimeter distances through a highly ordered network of fibers embedded in their cell envelope. The conductivity of these periplasmic wires is exceptionally high for a biological material, but their chemical structure and underlying electron transport mechanism remain unresolved. Here, we combine high-resolution microscopy, spectroscopy, and chemical imaging on individual cable bacterium filaments to demonstrate that the periplasmic wires consist of a conductive protein core surrounded by an insulating protein shell layer. The core proteins contain a sulfur-ligated nickel cofactor, and conductivity decreases when nickel is oxidized or selectively removed. The involvement of nickel as the active metal in biological conduction is remarkable, and suggests a hitherto unknown form of electron transport that enables efficient conduction in centimeter-long protein structures. Filamentous cable bacteria conduct electrical currents over centimeter distances through fibers embedded in their cell envelope. Here, Boschker et al. show that the fibers consist of a conductive core containing nickel proteins that is surrounded by an insulating protein shell. | Keywords: | Bacterial Proteins;Deltaproteobacteria;Electricity;Electron Transport;Nickel;Electric Conductivity | Document URI: | http://hdl.handle.net/1942/35528 | e-ISSN: | 2041-1723 | DOI: | 10.1038/s41467-021-24312-4 | ISI #: | 000669944900006 | Rights: | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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s41467-021-24312-4.pdf | Published version | 2.18 MB | Adobe PDF | View/Open |
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