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http://hdl.handle.net/1942/3555
Title: | Depletion of myelin-basic-protein autoreactive T-cells by T-cell vaccination - Pilot trial in multiple-sclerosis | Authors: | MEDAER, Rob STINISSEN, Piet RAUS, Jef ZHANG, JINGWU TRUYEN, L |
Issue Date: | 1995 | Publisher: | LANCET LTD | Source: | LANCET, 346(8978). p. 807-808 | Abstract: | In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after Vaccination in association with reappearance of circulating MBP-reactive T cells. | Notes: | FREE UNIV AMSTERDAM,ACAD HOSP,DEPT DIAGNOST RADIOL,AMSTERDAM,NETHERLANDS. CLIN DE MICK,MULTIPLE SCLEROSIS REHABIL UNIT,BRASSCHAAT,BELGIUM.MEDAER, R, LIMBURGS UNIV CENTRUM,DR L WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,B-3590 DLEPENBEEK,BELGIUM. | Document URI: | http://hdl.handle.net/1942/3555 | DOI: | 10.1016/S0140-6736(95)91622-9 | ISI #: | A1995RW25800013 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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