Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/35778
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dc.contributor.authorCuyx, Senne-
dc.contributor.authorSanto Ramalho, Anabela-
dc.contributor.authorCorthout, Nikky-
dc.contributor.authorFIEUWS, Steffen-
dc.contributor.authorFurstova, Eva-
dc.contributor.authorArnauts, Kaline-
dc.contributor.authorFerrante, Marc-
dc.contributor.authorVerfaillie, Catherine-
dc.contributor.authorMunck, Sebastian-
dc.contributor.authorBoon, Mieke-
dc.contributor.authorProesmans, Marijke-
dc.contributor.authorDupont, Lieven-
dc.contributor.authorDe Boeck, Kris-
dc.contributor.authorVermeulen, Francois-
dc.date.accessioned2021-11-05T14:20:24Z-
dc.date.available2021-11-05T14:20:24Z-
dc.date.issued2021-
dc.date.submitted2021-11-05T13:54:58Z-
dc.identifier.citationTHORAX, 76(11), p. 1146-1149.-
dc.identifier.issn0040-6376-
dc.identifier.urihttp://hdl.handle.net/1942/35778-
dc.description.abstractDiagnosing cystic fibrosis (CF) when sweat chloride is not in the CF range and less than 2 disease-causing CFTR mutations are found requires physiological CFTR assays, which are not always feasible or available. We developed a new physiological CFTR assay based on the morphological differences between rectal organoids from subjects with and without CF. In organoids from 167 subjects with and 22 without CF, two parameters derived from a semi-automated image analysis protocol (rectal organoid morphology analysis, ROMA) fully discriminated CF subjects with two disease-causing mutations from non-CF subjects (p<0.001). ROMA, feasible at all ages, can be centralised to improve standardisation.-
dc.description.sponsorshipBelgian CF patients' association "Mucovereniging/Association Muco"; Research Grant of the Belgian Society of Paediatrics BVK-SBP 2019; UZ Leuven Fund for Translational Biomedical Research-
dc.language.isoen-
dc.publisherBMJ PUBLISHING GROUP-
dc.subject.othercystic fibrosis-
dc.titleRectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis-
dc.typeJournal Contribution-
dc.identifier.epage1149-
dc.identifier.issue11-
dc.identifier.spage1146-
dc.identifier.volume76-
local.format.pages4-
local.bibliographicCitation.jcatA1-
dc.description.notesVermeulen, F (corresponding author), Katholieke Univ Leuven, Woman & Child Unit, CF Res Lab, Dept Dev & Regenerat, Leuven, Flanders, Belgium.-
dc.description.notesfrancois.vermeulen@uzleuven.be-
local.publisher.placeBRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1136/thoraxjnl-2020-216368-
dc.identifier.isiWOS:000709895600014-
dc.contributor.orcidCuyx, Senne/0000-0002-6473-8966; VERMEULEN,-
dc.contributor.orcidFrancois/0000-0003-2303-2470; Arnauts, Kaline/0000-0003-0872-7776;-
dc.contributor.orcidMunck, Sebastian/0000-0002-5182-5358; Santo Ramalho,-
dc.contributor.orcidAnabela/0000-0003-3143-3661-
dc.identifier.eissn1468-3296-
local.provider.typewosris-
local.description.affiliation[Cuyx, Senne; Santo Ramalho, Anabela; Boon, Mieke; Proesmans, Marijke; De Boeck, Kris; Vermeulen, Francois] Katholieke Univ Leuven, Woman & Child Unit, CF Res Lab, Dept Dev & Regenerat, Leuven, Flanders, Belgium.-
local.description.affiliation[Cuyx, Senne; Boon, Mieke; Proesmans, Marijke; De Boeck, Kris; Vermeulen, Francois] Univ Hosp Leuven, Dept Pediat, Pediat Pulmonol, Leuven, Flanders, Belgium.-
local.description.affiliation[Corthout, Nikky; Munck, Sebastian] VIB KU Leuven Ctr Brain & Dis Res, VIB Bio Imaging Core, Leuven, Belgium.-
local.description.affiliation[Corthout, Nikky; Munck, Sebastian] Katholieke Univ Leuven, Dept Neurosci, Leuven, Flanders, Belgium.-
local.description.affiliation[Fieuws, Steffen] Katholieke Univ Leuven, Interuniv Ctr Biostat & Stat Bioinformat, Leuven, Flanders, Belgium.-
local.description.affiliation[Fieuws, Steffen] Hasselt Univ, Interuniv Ctr Biostat & Stat Bioinformat, Hasselt, Limburg, Belgium.-
local.description.affiliation[Furstova, Eva] Motol Univ Hosp, Fac Med 2, Dept Pediat, Prague, Czech Republic.-
local.description.affiliation[Arnauts, Kaline; Ferrante, Marc] Katholieke Univ Leuven, Dept Chron Dis & Metab CHROMETA, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Flanders, Belgium.-
local.description.affiliation[Arnauts, Kaline; Verfaillie, Catherine] Katholieke Univ Leuven, Dept Dev & Regenerat, Stem Cell Inst Leuven SCIL, Leuven, Flanders, Belgium.-
local.description.affiliation[Ferrante, Marc] Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Leuven, Flanders, Belgium.-
local.description.affiliation[Dupont, Lieven] Univ Hosp Leuven, Dept Chron Dis Metab & Ageing, Leuven, Flanders, Belgium.-
local.description.affiliation[Dupont, Lieven] Univ Hosp Leuven, Pneumol, Leuven, Flanders, Belgium.-
local.description.affiliation[Dupont, Lieven] Univ Hosp Leuven, Dept Resp Dis, Leuven, Flanders, Belgium.-
local.uhasselt.internationalno-
item.contributorCuyx, Senne-
item.contributorSanto Ramalho, Anabela-
item.contributorCorthout, Nikky-
item.contributorFIEUWS, Steffen-
item.contributorFurstova, Eva-
item.contributorArnauts, Kaline-
item.contributorFerrante, Marc-
item.contributorVerfaillie, Catherine-
item.contributorMunck, Sebastian-
item.contributorBoon, Mieke-
item.contributorProesmans, Marijke-
item.contributorDupont, Lieven-
item.contributorDe Boeck, Kris-
item.contributorVermeulen, Francois-
item.fullcitationCuyx, Senne; Santo Ramalho, Anabela; Corthout, Nikky; FIEUWS, Steffen; Furstova, Eva; Arnauts, Kaline; Ferrante, Marc; Verfaillie, Catherine; Munck, Sebastian; Boon, Mieke; Proesmans, Marijke; Dupont, Lieven; De Boeck, Kris & Vermeulen, Francois (2021) Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis. In: THORAX, 76(11), p. 1146-1149..-
item.accessRightsClosed Access-
item.fulltextNo Fulltext-
item.validationecoom 2022-
crisitem.journal.issn0040-6376-
crisitem.journal.eissn1468-3296-
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