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Title: | Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016-2020) | Authors: | Verheyen, Veerle J. Remy, Sylvie Govarts, Eva Colles, Ann Rodriguez Martin, Laura Koppen, Gudrun Voorspoels, Stefan BRUCKERS, Liesbeth BIJNENS, Esmee VOS, Stijn Morrens, Bert Coertjens, Dries De Decker, Annelies Franken, Carmen Den Hond, Elly Nelen, Vera Covaci, Adrian Loots, Ilse De Henauw, Stefaan Van Larebeke, Nicolas Teughels, Caroline NAWROT, Tim Schoeters, Greet |
Issue Date: | 2021 | Publisher: | MDPI | Source: | TOXICS, 9 (10) (Art N° 245) | Abstract: | Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact of PAHs on endocrine stress and inflammation in adolescence. We examined 393 Flemish adolescents (14-15 years) cross-sectionally, measured urinary concentrations of hydroxylated naphthalene, fluorene, phenanthrene and pyrene metabolites, and calculated the sum of all measured metabolites. We determined hair cortisol concentration (HCC) as endocrine stress biomarker, leucocyte counts and neutrophil-lymphocyte ratio (NLR) in peripheral blood as inflammatory biomarkers, and urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) concentration as oxidative stress biomarker. Exposure-response associations were analyzed by multiple regression, adjusted for a priori selected covariates. A doubling of 1-hydroxypyrene concentration was associated with a factor of 1.13 (95% CI: 1.03, 1.24) increase in HCC and a factor of 1.07 (95% CI: 1.02, 1.13) increase in 8-oxodG. Doublings of 2- and 3-hydroxyphenanthrene concentrations were associated with a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.00, 1.12) increase in 8-oxodG, respectively. Doubling of 2-hydroxyphenanthrene and of the sum of 2- and 3-hydroxyfluorene was associated with, respectively, a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.01, 1.13) increase in NLR. Our results indicate the glucocorticoid pathway as a potential target for PAH exposure in adolescents and suggest oxidative stress, endocrine stress, and inflammation in adolescence as underlying mechanisms and early markers for PAH-related adverse health effects.</p> | Notes: | Verheyen, VJ (corresponding author), Flemish Inst Technol Res VITO, VITO Hlth, Boeretang 200, B-2400 Mol, Belgium.; Verheyen, VJ (corresponding author), Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. veerle.verheyen@vito.be; sylvie.remy@vito.be; eva.govarts@vito.be; ann.colles@vito.be; laura.rodriguezmartin@vito.be; gudrun.koppen@vito.be; stefan.voorspoels@vito.be; Liesbeth.bruckers@uhasselt.be; bert.morrens@uantwerpen.be; stijn.vos@uhasselt.be; bert.morrens@uantwerpen.be; dries.coertjens@uantwerpen.be; Annelies.DEDECKER@provincieantwerpen.be; Carmen.Franken@provincieantwerpen.be; elly.denhond@provincieantwerpen.be; vera.NELEN@provincieantwerpen.be; adrian.covaci@uantwerpen.be; ilse.loots@uantwerpen.be; stefaan.dehenauw@ugent.be; nicolas.vanlarebeke@ugent.be; caroline.teughels@vlaanderen.be; tim.nawrot@uhasselt.be; greet.schoeters@vito.be |
Keywords: | adolescents;human biomonitoring;Flemish Environment and Health Study (FLEHS);polycyclic aromatic hydrocarbons;hair cortisol concentration;neutrophil-lymphocyte ratio8-oxo-7;8-dihydro-2-deoxyguanosine | Document URI: | http://hdl.handle.net/1942/35861 | e-ISSN: | 2305-6304 | DOI: | 10.3390/toxics9100245 | ISI #: | WOS:000713416000001 | Rights: | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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toxics-09-00245-v2.pdf | Published version | 4.59 MB | Adobe PDF | View/Open |
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