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Title: | Glomerular function in relation to fine airborne particulate matter in a representative population sample | Authors: | Feng, YM Thijs, L Zhang , ZY BIJNENS, Esmee Yang, WY Wei, FF JANSSEN, Bram NAWROT, Tim Staessen, JA |
Issue Date: | 2021 | Publisher: | NATURE RESEARCH | Source: | Scientific reports (Nature Publishing Group), 11 (1) (Art N° 14646) | Abstract: | From 1990 until 2017, global air-pollution related mortality increased by 40%. Few studies addressed the renal responses to ultrafine particulate [<= 2.5 mu m (PM2.5)], including black carbon (BC), which penetrate into the blood stream. In a Flemish population study, glomerular filtration estimated from serum creatinine (eGFR) and the urinary albumin-to-creatinine ratio were measured in 2005-2009 in 820 participants (women, 50.7%; age, 51.1 years) with follow-up of 523 after 4.7 years (median). Serum creatinine, eGFR, chronic kidney disease (eGFR<60 mL/min/1.73 m(2)) and microalbuminuria (>3.5/>2.5 mg per mmol creatinine in women/men) were correlated in individual participants via their residential address with PM2.5 [median 13.1 (range 0.3-2.9) mu g/m(3)] and BC [1.1 (0.3-18) mu g/m(3)], using mixed models accounting for address clusters. Cross-sectional and longitudinally, no renal outcome was associated with PM2.5 or BC in models adjusted for sex and baseline or time varying covariables, including age, blood pressure, heart rate, body mass index, plasma glucose, the total-to-HDL serum cholesterol ratio, alcohol intake, smoking, physical activity, socioeconomic class, and antihypertensive treatment. The subject-level geocorrelations of eGFR change with to BC and PM2.5 were 0.13 and 0.02, respectively (P >= 0.68). In conclusion, in a population with moderate exposure, renal function was unrelated to ultrafine particulate. | Document URI: | http://hdl.handle.net/1942/35887 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-94136-1 | ISI #: | 000675839300013 | Rights: | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Glomerular function in relation to fine airborne particulate matter in a representative population sample.pdf | Published version | 1.42 MB | Adobe PDF | View/Open |
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