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http://hdl.handle.net/1942/3590
Title: | SUPERANTIGEN REACTIVITY OF GAMMA-DELTA T-CELL CLONES ISOLATED FROM PATIENTS WITH MULTIPLE-SCLEROSIS AND CONTROLS | Authors: | STINISSEN, Piet VANDEVYVER, CAROLINE RAUS, Jef ZHANG, JINGWU |
Issue Date: | 1995 | Publisher: | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Source: | CELLULAR IMMUNOLOGY, 166(2). p. 227-235 | Abstract: | gamma delta T cells have been implicated as playing a role in the demyelinating processes of multiple sclerosis (MS). However, the nature of the ligands which lead to activation and accumulation of gamma delta T cells in the brain lesions remains unknown. This study was undertaken to examine whether gamma delta T cells derived from cerebrospinal fluid and blood of MS patients could be stimulated by bacterial superantigens: staphylococcal enterotoxins A and B and toxic shock syndrome toxin-1. A panel of 16 gamma delta T cell clones isolated from MS patients and controls was found to react with the superantigens used at a nanogram range and displayed specific cytotoxic activity toward target cells pulsed with the corresponding superantigens. The responses of the gamma delta T cell clones did not require MHC-matched accessory cells and were not blocked by antibodies to the MHC molecules, suggesting a non-MHC restricted interaction. The superantigen reactivity was associated with both V delta 2(+)/V gamma 2(+) and V delta 1(+)/V gamma 1(+) subsets, reportedly found in the MS lesions. Our data suggest an alternative pathway which may account for gamma delta T cell activation in MS. (C) 1995 Academic Press, Inc. | Notes: | DR WILLEMS INST,BIOTECHNOL UNIT,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.STINISSEN, P, DR WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,DIEPENBEEK,BELGIUM. | Document URI: | http://hdl.handle.net/1942/3590 | DOI: | 10.1006/cimm.1995.9975 | ISI #: | A1995TK31300007 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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