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http://hdl.handle.net/1942/3593
Title: | Plasma-membrane-Bound mcromoleculas are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions? | Authors: | Vereb, G. Matyus, L. Bene, L. Panyi, G. Bacso, Z. Balazs, M. Matko, J. Szollosi, J. Gaspar, R. Damjanovich, S. DALE, Robert Pieri, C. AMELOOT, Marcel |
Issue Date: | 1995 | Publisher: | JOHN WILEY & SONS LTD | Source: | JOURNAL OF MOLECULAR RECOGNITION, 8(4). p. 237-246 | Abstract: | Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level. | Notes: | UNIV MED SCH DEBRECEN,DEPT BIOPHYS,H-4012 DEBRECEN,HUNGARY. CHRISTIE HOSP NATL HLTH SERV TRUST,CANC RES CAMPAIGN,PATERSON INST CANC RES,MANCHESTER M20 9BX,LANCS,ENGLAND. INRCA ANCONA,DEPT GERONTOL & GERIAT,CTR CITOL,ANCONA,ITALY. LIMBURGS UNIV CTR,PHYSIOL RES GRP,B-3590 DIEPENBEEK,BELGIUM. | Keywords: | CELL SURFACE; MOLECULAR PATTERN; ENERGY TRANSFER; FLUORESCENCE; FLOW CYTOMETRY; TRANSMEMBRANE POTENTIAL; MHC; ANTIGEN PRESENTATION; INTERCELLULAR COMMUNICATION | Document URI: | http://hdl.handle.net/1942/3593 | DOI: | 10.1002/jmr.300080402 | ISI #: | A1995TF18900001 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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