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Title: | Lipophagy: a new player in CNS disorders | Authors: | LOIX, Melanie BOGIE, Jeroen HENDRIKS, Jerome HAIDAR, Mansour |
Issue Date: | 2021 | Publisher: | ELSEVIER SCIENCE LONDON | Source: | Trends in endocrinology and metabolism, 32 (11) , p. 941 -951 | Abstract: | Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent years, disruption of autophagy and accumulation of LDs have been reported as pathological hallmarks in several neurodegenerative and neuroinflammatory diseases, raising the question whether lipophagy is a process that is important in the progression of these disorders. This supports the growing interest in lipid metabolism as a major player in neurodegeneration, and the emerging understanding of several neurological pathologies as not only proteinopathies but also lipidopathies. In this review we discuss the importance of lipophagy in the most common central nervous system diseases. We examine the latest evidence for the reported interplay between abnormalities in lipid accumulation and autophagy, and propose lipophagy as a potentially important mechanism in neurodegeneration. | Notes: | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. jerome.hendriks@uhasselt.be |
Document URI: | http://hdl.handle.net/1942/35938 | ISSN: | 1043-2760 | e-ISSN: | 1879-3061 | DOI: | 10.1016/j.tem.2021.08.010 | ISI #: | WOS:000707636500010 | Rights: | © 2021 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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