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http://hdl.handle.net/1942/35979
Title: | Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons | Authors: | MUNUSWAMY, Revathy Derave, Wim DE BRANDT, Jana BURTIN, Chris AUMANN, Joseph SPRUIT, Martijn A. MICHIELS, Luc |
Issue Date: | 2021 | Publisher: | DOVE MEDICAL PRESS LTD | Source: | JOURNAL OF INFLAMMATION RESEARCH, 14 , p. 4503 -4507 | Abstract: | Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation. | Notes: | Michiels, L (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Fac Med & Life Sci, Hasselt, Belgium. luc.michiels@uhasselt.be |
Keywords: | COPD;Dlow-grade systemic inflammation;pCRP;mCRP | Document URI: | http://hdl.handle.net/1942/35979 | e-ISSN: | 1178-7031 | DOI: | 10.2147/JIR.S320659 | ISI #: | WOS:000703153600005 | Rights: | © 2021 Munuswamy et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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JIR_A_320659 4503..4507.pdf | Published version | 1.47 MB | Adobe PDF | View/Open |
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