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Title: | Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT-An Experimental In Vitro and In Vivo Study | Authors: | D'Hollander, Antoine Van Roosbroeck, Ruben Trekker, Jesse Stakenborg, Tim Dresselaers, Tom Vande Velde, Greetje STRUYS, Tom LAMBRICHTS, Ivo Lammertyn, Jeroen Lagae, Liesbet Himmelreich, Uwe |
Issue Date: | 2021 | Publisher: | MDPI | Source: | Pharmaceutics (Basel), 13 (9) (Art N° 1494) | Abstract: | The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for in vitro cell labeling and in vivo cell tracking using magnetic resonance imaging (MRI) and computed tomography (CT). SAF-NP-labeled cells showed high contrast in MRI phantom studies (r(2)* = 712 s(-1) mM(-1)), while pelleted cells showed clear contrast enhancement in CT. After intravenous SAF-NP injection, nanoparticles accumulated in the liver and spleen, as visualized in vivo by significant MRI contrast enhancement. Intravenous injection of SAF-NP-labeled cells resulted in cell accumulation in the lungs, which was clearly detectable by using CT but not by using MRI. SAF-NPs proved to be very efficient cell labeling agents for complementary MRI- and CT-based cell tracking. Bimodal monitoring of SAF-NP labeled cells is in particular of interest for applications where the applied imaging methods are not able to visualize the particles and/or cells in all organs. | Notes: | Himmelreich, U (corresponding author), Katholieke Univ Leuven, Biomed MRI Unit, Dept Imaging & Pathol, O&N 1,Herestr 49, B-3000 Leuven, Belgium.; Himmelreich, U (corresponding author), IMEC, Dept Life Sci Technol, Kapeldreef 75, B-3001 Leuven, Belgium. antoinedhollander@hotmail.com; ruben.vanroosbroeck@gmail.com; jessetrekker@gmail.com; Tim.Stakenborg@imec.be; tom.dresselaers@uzleuven.be; Greetje.Vandevelde@kuleuven.be; tom.struys@sprofit.com; ivo.lambrichts@uhasselt.be; jeroen.lammertyn@kuleuven.be; liesbet.lagae@imec.be; uwe.himmelreich@kuleuven.be |
Keywords: | magnetic resonance imaging;MRI;computed tomography;CT;antiferromagnetic nanoparticlesgold nanoparticle;stop down synthesis;bimodal contrast agent | Document URI: | http://hdl.handle.net/1942/35992 | e-ISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics13091494 | ISI #: | 000701471400001 | Rights: | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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pharmaceutics-13-01494.pdf | Published version | 5.52 MB | Adobe PDF | View/Open |
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