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Title: | Detection of a Hemoglobin Adduct of the Food Contaminant Furfuryl Alcohol in Humans: Levels of N-((Furan-2-yl)methyl)-valine in Two Epidemiological Studies | Authors: | Monien, Bernhard H. Bergau, Nick HOGERVORST, Janneke NAWROT, Tim Trefflich, Iris Weikert, Cornelia Abraham, Klaus |
Issue Date: | 2021 | Publisher: | WILEY | Source: | MOLECULAR NUTRITION & FOOD RESEARCH, 65(23), (Art N° 2100584) | Abstract: | Scope Furfuryl alcohol is a heat-induced food contaminant, classified as possibly carcinogenic to humans. The proximal carcinogen 2-sulfoxymethylfuran leads to adduct formation in DNA and proteins (e.g., N-((furan-2-yl)methyl)-Val (FFA-Val) in hemoglobin). Methods and results This study analyzed human erythrocyte samples from two studies for the presence of FFA-Val: the Risks and Benefits of a Vegan Diet study (RBVD; 72 adults) and the ENVIRonmental influence ON early AGEing birth cohort study (ENVIRONAGE; 100 mother-newborn pairs). In the RBVD study, FFA-Val levels are lower in vegans compared to omnivores (median 13.0 vs 15.8 pmol g(-1) hemoglobin, p = 0.008), and lower in non-smokers compared to smokers (median 14.1 vs 17.0 pmol g(-1) hemoglobin, p = 0.003). In the birth cohort, FFA-Val levels are distinctly higher in maternal compared to newborn samples (median 15.2 vs 2.2 pmol g(-1) hemoglobin, p < 0.001). Conclusions FFA-Val, hitherto detected only in blood samples of mice, is quantifiable in all human samples, indicating a general exposure to furfuryl alcohol. The low adduct levels in blood samples from newborn children suggested that the placenta is a barrier to furfuryl alcohol. Dietary habits and tobacco smoking are two main influencing factors on the formation of FFA-Val, which may be of use as a biomarker of exposure to furfuryl alcohol. | Notes: | Monien, BH (corresponding author), German Fed Inst Risk Assessment BfR, Dept Food Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany. bernhard.monien@bfr.bund.de |
Keywords: | birth cohort; coffee; cord blood; furfuryl alcohol; hemoglobin adducts;;vegan diet | Document URI: | http://hdl.handle.net/1942/36031 | ISSN: | 1613-4125 | e-ISSN: | 1613-4133 | DOI: | 10.1002/mnfr.202100584 | ISI #: | 000713103100001 | Rights: | © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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