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http://hdl.handle.net/1942/36196
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DC Field | Value | Language |
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dc.contributor.author | Boeckmans, J | - |
dc.contributor.author | Rombaut, M | - |
dc.contributor.author | Demuyser, T | - |
dc.contributor.author | Declerck , B | - |
dc.contributor.author | Pierard, D | - |
dc.contributor.author | Rogiers, V | - |
dc.contributor.author | De Kock, J | - |
dc.contributor.author | WAUMANS, Luc | - |
dc.contributor.author | MAGERMAN, Koen | - |
dc.contributor.author | Cartuyvels , R | - |
dc.contributor.author | RUMMENS, Jean-Luc | - |
dc.contributor.author | Rodrigues, RM | - |
dc.contributor.author | Vanhaecke, T | - |
dc.date.accessioned | 2021-12-15T09:05:59Z | - |
dc.date.available | 2021-12-15T09:05:59Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-09-13T13:55:32Z | - |
dc.identifier.citation | Archives of toxicology, 95 (7) , p. 2235 -2253 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36196 | - |
dc.description.abstract | Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease that affects about a quarter of the world population. MAFLD encompasses different disease stadia ranging from isolated liver steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Although MAFLD is considered as the hepatic manifestation of the metabolic syndrome, multiple concomitant disease-potentiating factors can accelerate disease progression. Among these risk factors are diet, lifestyle, genetic traits, intake of steatogenic drugs, male gender and particular infections. Although infections often outweigh the development of fatty liver disease, pre-existing MAFLD could be triggered to progress towards more severe disease stadia. These combined disease cases might be underreported because of the high prevalence of both MAFLD and infectious diseases that can promote or exacerbate fatty liver disease development. In this review, we portray the molecular and cellular mechanisms by which the most relevant viral, bacterial and parasitic infections influence the progression of fatty liver disease and steatohepatitis. We focus in particular on how infectious diseases, including coronavirus disease-19, hepatitis C, acquired immunodeficiency syndrome, peptic ulcer and periodontitis, exacerbate MAFLD. We specifically underscore the synergistic effects of these infections with other MAFLD-promoting factors. | - |
dc.description.sponsorship | This work was funded by grants of Research Foundation Flanders (1S10518N, 12H2216N, 1S73019N and G042019N), Onderzoeksraad Vrije Universiteit Brussel and the Research Chair Mireille Aerens for the development Alternatives to Animal Testing | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.rights | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 | - |
dc.subject.other | Metabolic-associated fatty liver disease (MAFLD) | - |
dc.subject.other | Non-alcoholic steatohepatitis (NASH) | - |
dc.subject.other | Infectious diseases | - |
dc.subject.other | Lipid metabolism | - |
dc.subject.other | Liver | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Human immunodeficiency virus | - |
dc.subject.other | Hepatitis C | - |
dc.subject.other | Helicobacter pylori | - |
dc.subject.other | Klebsiella pneumoniae | - |
dc.title | Infections at the nexus of metabolic-associated fatty liver disease | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2253 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 2235 | - |
dc.identifier.volume | 95 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1007/s00204-021-03069-1 | - |
dc.identifier.pmid | 34027561 | - |
dc.identifier.isi | 000653175400002 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Boeckmans, J; Rombaut, M; Demuyser, T; Declerck , B; Pierard, D; Rogiers, V; De Kock, J; WAUMANS, Luc; MAGERMAN, Koen; Cartuyvels , R; RUMMENS, Jean-Luc; Rodrigues, RM & Vanhaecke, T (2021) Infections at the nexus of metabolic-associated fatty liver disease. In: Archives of toxicology, 95 (7) , p. 2235 -2253. | - |
item.contributor | Boeckmans, J | - |
item.contributor | Rombaut, M | - |
item.contributor | Demuyser, T | - |
item.contributor | Declerck , B | - |
item.contributor | Pierard, D | - |
item.contributor | Rogiers, V | - |
item.contributor | De Kock, J | - |
item.contributor | WAUMANS, Luc | - |
item.contributor | MAGERMAN, Koen | - |
item.contributor | Cartuyvels , R | - |
item.contributor | RUMMENS, Jean-Luc | - |
item.contributor | Rodrigues, RM | - |
item.contributor | Vanhaecke, T | - |
crisitem.journal.issn | 0340-5761 | - |
crisitem.journal.eissn | 1432-0738 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Infections at the nexus of metabolic-associated fatty liver disease.pdf | Published version | 1.74 MB | Adobe PDF | View/Open |
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