Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/3625
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | ZHANG, JINGWU | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-29T09:38:21Z | - |
dc.date.available | 2007-11-29T09:38:21Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | ACTA NEUROLOGICA BELGICA, 94(2). p. 112-115 | - |
dc.identifier.issn | 0300-9009 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3625 | - |
dc.description.abstract | Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor frequency of the MBP-specific T cells dropped to undetectable levels in all patients. Injection of attenuated MBP-specific T cells gave rise to a pronounced response of anti-clonotypic T cells and a limited anti-ergotypic response. The anti-clonotypic T cells proliferated in the presence of the vaccine clones and were inhibitory and cytotoxic for the same vaccine clones. This clinical trial shows for the first time that antigen specific T cell vaccination in humans is feasible. The results obtained are highly promising for future treatments of Multiple Sclerosis and other autoimmune diseases. | - |
dc.language.iso | en | - |
dc.publisher | ACTA MEDICA BELGICA | - |
dc.subject.other | MULTIPLE SCLEROSIS; MBP-SPECIFIC T CELLS; T CELL VACCINATION | - |
dc.title | T-cell vaccination in multiple-sclerosis - hopes and facts | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 115 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 112 | - |
dc.identifier.volume | 94 | - |
local.format.pages | 4 | - |
dc.description.notes | LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1994NU94600007 | - |
dc.identifier.url | http://www.actaneurologica.be/acta/article.asp?lang=en&navid=137&id=464&mod=acta | - |
item.fullcitation | ZHANG, JINGWU & RAUS, Jef (1994) T-cell vaccination in multiple-sclerosis - hopes and facts. In: ACTA NEUROLOGICA BELGICA, 94(2). p. 112-115. | - |
item.fulltext | No Fulltext | - |
item.contributor | ZHANG, JINGWU | - |
item.contributor | RAUS, Jef | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
WEB OF SCIENCETM
Citations
6
checked on Sep 28, 2024
Page view(s)
14
checked on Sep 7, 2022
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.