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http://hdl.handle.net/1942/3625
Title: | T-cell vaccination in multiple-sclerosis - hopes and facts | Authors: | ZHANG, JINGWU RAUS, Jef |
Issue Date: | 1994 | Publisher: | ACTA MEDICA BELGICA | Source: | ACTA NEUROLOGICA BELGICA, 94(2). p. 112-115 | Abstract: | Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor frequency of the MBP-specific T cells dropped to undetectable levels in all patients. Injection of attenuated MBP-specific T cells gave rise to a pronounced response of anti-clonotypic T cells and a limited anti-ergotypic response. The anti-clonotypic T cells proliferated in the presence of the vaccine clones and were inhibitory and cytotoxic for the same vaccine clones. This clinical trial shows for the first time that antigen specific T cell vaccination in humans is feasible. The results obtained are highly promising for future treatments of Multiple Sclerosis and other autoimmune diseases. | Notes: | LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. | Keywords: | MULTIPLE SCLEROSIS; MBP-SPECIFIC T CELLS; T CELL VACCINATION | Document URI: | http://hdl.handle.net/1942/3625 | Link to publication/dataset: | http://www.actaneurologica.be/acta/article.asp?lang=en&navid=137&id=464&mod=acta | ISI #: | A1994NU94600007 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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