Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/36509
Title: Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus
Authors: VAN RYCKEGHEM, Lisa 
KEYTSMAN, Charly 
DE BRANDT, Jana 
VERBOVEN, Kenneth 
Verbaanderd, Elvire
MARINUS, Nastasia 
FRANSSEN, Wouter 
FREDERIX, Ines 
Bakelants, Elise
Petit, Thibault
Jogani, Siddharth
Stroobants, Sarah
DENDALE, Paul 
BITO, Virginie 
VERWERFT, Jan 
HANSEN, Dominique 
Issue Date: 2022
Publisher: Springer
Source: European journal of applied physiology (Print),
Status: Early view
Abstract: Purpose Exercise training improves exercise capacity in type 2 diabetes mellitus (T2DM). It remains to be elucidated whether such improvements result from cardiac or peripheral muscular adaptations, and whether these are intensity dependent. Methods 27 patients with T2DM [without known cardiovascular disease (CVD)] were randomized to high-intensity interval training (HIIT, n = 15) or moderate-intensity endurance training (MIT, n = 12) for 24 weeks (3 sessions/week). Exercise echocardiography was applied to investigate cardiac output (CO) and oxygen (O 2) extraction during exercise, while exercise capacity [(̇ VO 2peak (mL/kg/min)] was examined via cardiopulmonary exercise testing at baseline and after 12 and 24 weeks of exercise training, respectively. Changes in glycaemic control (HbA1c and glucose tolerance), lipid profile and body composition were also evaluated. Results 19 patients completed 24 weeks of HIIT (n = 10, 66 ± 11 years) or MIT (n = 9, 61 ± 5 years). HIIT and MIT similarly improved glucose tolerance (p Time = 0.001, p Interaction > 0.05), ̇ VO 2peak (mL/kg/min) (p Time = 0.001, p Interaction > 0.05), and exercise performance (W peak) (p Time < 0.001, p Interaction > 0.05). O 2 extraction increased to a greater extent after 24 weeks of MIT (56.5%, p 1 = 0.009, p Time = 0.001, p Interaction = 0.007). CO and left ventricular longitudinal strain (LS) during exercise remained unchanged (p Time > 0.05). A reduction in HbA1c was correlated with absolute changes in LS after 12 weeks of MIT (r = − 0.792, p = 0.019, LS at rest) or HIIT (r = − 0.782, p = 0.038, LS at peak exercise). Conclusion In patients with well-controlled T2DM, MIT and HIIT improved exercise capacity, mainly resulting from increments in O 2 extraction capacity, rather than changes in cardiac output. In particular, MIT seemed highly effective to generate these peripheral adaptations. Trial Registration NCT03299790, initially released 09/12/2017.
Keywords: Stress echocardiography;Left-ventricular function;Type 2 diabetes;Exercise tolerance;Exercise training
Document URI: http://hdl.handle.net/1942/36509
ISSN: 1439-6319
e-ISSN: 1439-6327
DOI: 10.1007/s00421-022-04884-9
ISI #: 000743390600002
Rights: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
Category: A1
Type: Journal Contribution
Validations: ecoom 2023
Appears in Collections:Research publications

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