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http://hdl.handle.net/1942/3654
Title: | The direct renal tubular effect of angiotensin-II in chicken | Authors: | CUYPERS, Y McConaghey, P. STEELS, Paul |
Issue Date: | 1993 | Publisher: | KARGER | Source: | RENAL PHYSIOLOGY AND BIOCHEMISTRY, 16(6). p. 325-332 | Abstract: | Taking advantage of the particular renal vascular arrangement in cocks, angiotensin II was injected (0.12-0.96 mu g/min) into the portal system of one kidney in order to increase the angiotensin-II concentration in the physiological nanomolar range at the level. of the renal tubules. Angiotensin II induced an increase in blood pressure of 5% and a bilateral rise in glomerular filtration rate and effective renal plasma now of 28 and 22%, respectively. The urine volume increased five times on the infused side and three times on the control side. The Na+ excretion increased 14 times on the infused side and only seven times on the control side. During angiotensin infusion, the fractional water excretion was 4.9% on the infused side and 2.9% on th e control side versus 1.1 and 1.2% during the control period. For the fractional Na+ excretion, the respective values were 2 and 1.2% versus 0.2 and 0.2% during the control period. The differences between the two kidneys demonstrate the direct tubular action of angiotensin II, inhibiting the tubular Na+ and water reabsorption at physiological nanomolar concentrations. Angiotensin seems thus to play an important intrarenal role. | Notes: | LIMBURGS UNIV CENTRUM,FYSIOL LAB,B-3390 DIEPENBEEK,BELGIUM. | Keywords: | ANGIOTENSIN II; EFFECTIVE RENAL PLASMA FLOW; GLOMERULAR FILTRATION RATE; K+ EXCRETION; NA+ EXCRETION; RENAL TUBULAR TRANSPORT; SPERBER TECHNIQUE | Document URI: | http://hdl.handle.net/1942/3654 | ISI #: | A1993MJ67300004 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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