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Title: | Biocompatibility Testing of Liquid Metal as an Interconnection Material for Flexible Implant Technology | Authors: | Foremny, Katharina NAGELS, Steven Kreienmeyer, Michaela Doll, Theodor DEFERME, Wim |
Issue Date: | 2021 | Publisher: | MDPI | Source: | NANOMATERIALS, 11 (12) (Art N° 3251) | Abstract: | Galinstan, a liquid metal at room temperature, is a promising material for use in flexible electronics. Since it has been successfully integrated in devices for external use, e.g., as stretchable electronic skin in tactile sensation, the possibility of using galinstan for flexible implant technology comes to mind. Usage of liquid metals in a flexible implant would reduce the risk of broken conductive pathways in the implants and therefore reduce the possibility of implant failure. However, the biocompatibility of the liquid metal under study, i.e., galinstan, has not been proven in state-of-the-art literature. Therefore, in this paper, a material combination of galinstan and silicone rubber is under investigation regarding the success of sterilization methods and to establish biocompatibility testing for an in vivo application. First cell biocompatibility tests (WST-1 assays) and cell toxicity tests (LDH assays) show promising results regarding biocompatibility. This work paves the way towards the successful integration of stretchable devices using liquid metals embedded in a silicone rubber encapsulant for flexible surface electro-cortical grid arrays and other flexible implants. | Notes: | Foremny, K (corresponding author), Hannover Med Sch, ORL Dept, Carl Neuberg Str 1, D-30625 Hannover, Germany.; Foremny, K (corresponding author), Cluster Excellence Hearing4All, Carl Neuberg Str 1, D-30625 Hannover, Germany. foremny.katharina@mh-hannover.de; steven.nagels@uhasselt.be; kreienmeyer.michaela@mh-hannover.de; doll.theodor@mh-hannover.de; wim.deferme@uhasselt.be |
Keywords: | galinstan;silicone rubber;sterilization;biocompatibility;bacteria;in-vivo | Document URI: | http://hdl.handle.net/1942/36551 | e-ISSN: | 2079-4991 | DOI: | 10.3390/nano11123251 | ISI #: | 000736321100001 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Biocompatibility Testing of Liquid Metal as an Interconnection Material for Flexible Implant Technology.pdf | Published version | 1.46 MB | Adobe PDF | View/Open |
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