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http://hdl.handle.net/1942/365
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DC Field | Value | Language |
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dc.contributor.author | Lipsitz, Stuart | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Fitzmaurice, Garrett | - |
dc.contributor.author | IBRAHIM, Joseph | - |
dc.date.accessioned | 2004-10-25T11:59:35Z | - |
dc.date.available | 2004-10-25T11:59:35Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Biometrics, 56(2). p. 528-536 | - |
dc.identifier.issn | 0006-341X | - |
dc.identifier.uri | http://hdl.handle.net/1942/365 | - |
dc.description.abstract | This paper considers a modification of generalized estimating equations (GEE) for handling missing binary response data. The proposed method uses Gaussian estimation of the correlation parame- ters, i.e., the estimating function that yields an estimate of the correlation parameters is obtained from the multivariate normal likelihood. The proposed method yields consistent estimates of the regression param- eters when data are missing completely at random (MCAR). However, when data are missing at random (MAR), consistency may not hold. In a simulation study with repeated binary outcomes that are missing at random, the magnitude of the potential bias that can arise is examined. The results of the simulation study indicate that, when the working correlation matrix is correctly specified, the bias is almost negligible for the modified GEE. In the simulation study, the proposed modification of GEE is also compared to the standard GEE, multiple imputation, and weighted estimating equations approaches. Finally, the proposed method is illustrated using data from a longitudinal clinical trial comparing two therapeutic treatments, zidovudine (AZT) and didanosine (ddI), in patients with HIV. | - |
dc.description.sponsorship | We are grateful for the support provided by grants CA 57253, CA 55576, CA 70101-01, CA 74015-01, and GM 29745 from the NIH, by funding from the National Fonds voor Weten- schappelijk Onderzoek (Belgium), and by NATO collabora- tive research grant G50648. | - |
dc.language.iso | en | - |
dc.publisher | INTERNATIONAL BIOMETRIC SOC | - |
dc.subject | Categorical data | - |
dc.subject | Missing data | - |
dc.subject | Longitudinal data | - |
dc.subject.other | binary response; missing data; multiple imputation; weighted estimating equations | - |
dc.title | GEE with Gaussian estimation of the correlations when data are incomplete | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 536 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 528 | - |
dc.identifier.volume | 56 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1111/j.0006-341X.2000.00528.x | - |
dc.identifier.isi | 000087677500028 | - |
item.fullcitation | Lipsitz, Stuart; MOLENBERGHS, Geert; Fitzmaurice, Garrett & IBRAHIM, Joseph (2000) GEE with Gaussian estimation of the correlations when data are incomplete. In: Biometrics, 56(2). p. 528-536. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2001 | - |
item.contributor | Lipsitz, Stuart | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Fitzmaurice, Garrett | - |
item.contributor | IBRAHIM, Joseph | - |
item.accessRights | Restricted Access | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Lipsitz_et_al-2000-Biometrics (1).pdf Restricted Access | Published version | 896.58 kB | Adobe PDF | View/Open Request a copy |
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