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http://hdl.handle.net/1942/365
Title: | GEE with Gaussian estimation of the correlations when data are incomplete | Authors: | Lipsitz, Stuart MOLENBERGHS, Geert Fitzmaurice, Garrett IBRAHIM, Joseph |
Issue Date: | 2000 | Publisher: | INTERNATIONAL BIOMETRIC SOC | Source: | Biometrics, 56(2). p. 528-536 | Abstract: | This paper considers a modification of generalized estimating equations (GEE) for handling missing binary response data. The proposed method uses Gaussian estimation of the correlation parame- ters, i.e., the estimating function that yields an estimate of the correlation parameters is obtained from the multivariate normal likelihood. The proposed method yields consistent estimates of the regression param- eters when data are missing completely at random (MCAR). However, when data are missing at random (MAR), consistency may not hold. In a simulation study with repeated binary outcomes that are missing at random, the magnitude of the potential bias that can arise is examined. The results of the simulation study indicate that, when the working correlation matrix is correctly specified, the bias is almost negligible for the modified GEE. In the simulation study, the proposed modification of GEE is also compared to the standard GEE, multiple imputation, and weighted estimating equations approaches. Finally, the proposed method is illustrated using data from a longitudinal clinical trial comparing two therapeutic treatments, zidovudine (AZT) and didanosine (ddI), in patients with HIV. | Keywords: | binary response; missing data; multiple imputation; weighted estimating equations | Document URI: | http://hdl.handle.net/1942/365 | DOI: | 10.1111/j.0006-341X.2000.00528.x | ISI #: | 000087677500028 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2001 |
Appears in Collections: | Research publications |
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Lipsitz_et_al-2000-Biometrics (1).pdf Restricted Access | Published version | 896.58 kB | Adobe PDF | View/Open Request a copy |
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