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Title: | A long-term study of liver-related events in Caucasian hepatitis B patients with normal ALT values and high viremia | Authors: | KOC, Ozgur Verbeek, J. Koek, G. H. BIELEN, Rob BUSSCHOTS, Dana Gamil, M. ROBAEYS, Geert Nevens , F. |
Issue Date: | 2022 | Publisher: | UNIV CATHOLIQUE LOUVAIN-UCL | Source: | ACTA GASTRO-ENTEROLOGICA BELGICA, 85 (1) , p. 56 -61 | Abstract: | Background and study aims: There is ongoing debate whether antiviral therapy should be initiated in hepatitis B e antigen (HBeAg)-negative patients with normal alanine aminotransferase (ALT) levels but high HBV DNA levels >2,000 IU/mL. Since the need for antiviral therapy might be different between Asian and Caucasian patients, we studied the long-term disease outcome in Caucasian patients living in Western Europe. Patients and methods: One hundred sixteen patients with high HBV DNA levels (>2,000 IU/mL) at diagnosis were included in the high viremia group, while those with HBV DNA <2,000 IU/ mL were used as controls (n = 327). All patients were Caucasian, HBeAg negative, had normal ALT levels and had no significant liver disease at diagnosis. Results: Median follow-up was 7 + 9.8 years in the high viremia group and this was 10 + 12.5 years in controls. The cumulative probability of a liver-related event over 10 years was 4.8% vs 0.0% in the control group (p=.008). In multivariable analysis, high viremia group was associated with the occurrence of a liver-related event (hazards ratio (HR) 95% confidence interval (CI): 1.20-11.98, p=.023). In this subgroup, older age at diagnosis (HR 95% CI: 1.011.16, p=.023) predicted a higher risk of liver-related event. In the high viremia group, liver-related mortality was 0.9% and none of the patients developed hepatocellular carcinoma. Conclusions: HBV DNA >2,000 IU/mL influences the long-term disease outcome in Caucasian HBeAg-negative patients living in Western Europe. Nevertheless, the risk of liver-related events is low. (Acta gastroenterol. belg., 2022, 85, 56-61). | Notes: | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. ozgur.koc@uhasselt.be |
Keywords: | hepatitis B;Caucasian;inactive carrier;ALT;HBV DNA | Document URI: | http://hdl.handle.net/1942/36662 | ISSN: | 1784-3227 | e-ISSN: | 1784-3227 | DOI: | 10.51821/85.1.9160 | ISI #: | 000752361200001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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10-Koc.pdf | Published version | 403 kB | Adobe PDF | View/Open |
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