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Title: | Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity | Authors: | Maifeld, Andras Wild, Johannes Karlsen, Tine, V Rakova, Natalia Wistorf, Elisa Linz, Peter Jung , Rebecca Birukov, Anna Gimenez-Rivera, Vladimir-Andrey Wilck, Nicola Bartolomaeus, Theda Dechend, Ralf KLEINEWIETFELD, Markus Forslund, Sofia K. Krause, Andreas Kokolakis, Georgios Philipp, Sandra Clausen, Bjoern E. Brand , Anna Waisman, Ari Kurschus, Florian C. Wegner, Joanna Schultheis, Michael Luft, Friedrich C. Boschmann, Michael Kelm, Marcus Wiig, Helge Kuehne, Titus Muller, Dominik N. Karbach, Susanne Marko, Lajos |
Issue Date: | 2022 | Publisher: | ELSEVIER SCIENCE INC | Source: | JOURNAL OF INVESTIGATIVE DERMATOLOGY, 142 (1) , p. 166 --+ | Abstract: | Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17. producing T helper 17 cells play a crucial role. In an observational study, we measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging. Patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASI or healthy controls. Skin sodium concentrations measured by Sodium-23 spectroscopy or by atomic absorption spectrometry in ashed-skin biopsies verified the findings with Sodium-23 magnetic resonance imaging. In vitro T helper 17 cell differentiation of naive CD4(+) cells from patients with psoriasis markedly induced IL-17A expression under increased sodium chloride concentrations. The imiquimod-induced psoriasis mouse model replicated the human findings. Extracellular tracer Chromium-51-EDTA measurements in imiquimod- and sham-treated skin showed similar extracellular volumes, rendering excessive water of intracellular origin. Chronic genetic IL-17A-driven psoriasis mouse models underlined the role of IL-17A in dermal sodium accumulation and inflammation. Our data describe skin sodium as a pathophysiological feature of psoriasis, which could open new avenues for its treatment. | Notes: | Marko, L (corresponding author), Charite Univ Med Berlin, Expt & Clin Res Ctr, Lindenberger Weg 80, D-13125 Berlin, Germany.; Marko, L (corresponding author), Max Delbrack Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany. lajos.marko@charite.de |
Document URI: | http://hdl.handle.net/1942/36668 | ISSN: | 0022-202X | e-ISSN: | 1523-1747 | DOI: | 10.1016/j.jid.2021.06.013 | ISI #: | 000748758900025 | Rights: | 2021 The Authors. Published by Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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1-s2.0-S0022202X21014238-main.pdf Restricted Access | Published version | 3.98 MB | Adobe PDF | View/Open Request a copy |
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