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http://hdl.handle.net/1942/36883
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DC Field | Value | Language |
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dc.contributor.author | Mamouris, Pavlos | - |
dc.contributor.author | Henrard, Severine | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Verhaegen, Jan | - |
dc.contributor.author | Lin , Guohao | - |
dc.contributor.author | Vaes , Bert | - |
dc.date.accessioned | 2022-03-10T15:35:43Z | - |
dc.date.available | 2022-03-10T15:35:43Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-02-16T09:05:11Z | - |
dc.identifier.citation | JOURNAL OF CLINICAL EPIDEMIOLOGY, 143 , p. 118 -127 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36883 | - |
dc.description.abstract | Objectives: We estimated the effect of pneumococcal vaccination (PV) on acute lower respiratory tract infections (LRTIs) in various age and risk groups using different methods within a causal inference methodological framework. Study design and setting: We used data from a general practitioners' morbidity registry for the year 2019. Both traditional statistical methods (regression-based and propensity score methods) and machine learning techniques were deployed. Multiple imputation was used to account for missing data. Relative risks (RRs) with 95% confidence intervals were estimated. Sensitivity analyses were performed to account for the severity of LRTIs and differences in vaccination registration. Results: All methods showed a standardized mean difference below 0.1 for each covariate. No method was found to be superior to another. PV (combination of conjugate and polysaccharide vaccine) had an overall protective effect for severe LRTIs. PV was protective in different age and risk groups, especially in people aged 50-84 years with an intermediate risk group. Conclusion: Using several techniques, PV was found to prevent severe LRTIs and confirmed the recommendations of the Belgian Superior Health Council. (c) 2021 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This research received no external funding. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2021 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Pneumococcal vaccine | - |
dc.subject.other | Relative risk | - |
dc.subject.other | Causal inference | - |
dc.subject.other | Propensity score | - |
dc.subject.other | Registry data | - |
dc.subject.other | Machine learning | - |
dc.title | Pneumococcal vaccination prevented severe LRTIs in adults: a causal inference framework applied in registry data | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 127 | - |
dc.identifier.spage | 118 | - |
dc.identifier.volume | 143 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mamouris, P (corresponding author), Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium. | - |
dc.description.notes | pavlos.mamouris@kuleuven.be | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jclinepi.2021.12.008 | - |
dc.identifier.isi | WOS:000740331000010 | - |
dc.contributor.orcid | Vaes, Bert/0000-0001-5244-1930; Mamouris, Pavlos/0000-0001-7902-5355; | - |
dc.contributor.orcid | Lin, Guohao/0000-0002-7935-3081 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mamouris, Pavlos; Lin, Guohao; Vaes, Bert] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium. | - |
local.description.affiliation | [Henrard, Severine] Catholic Univ Louvain, Louvain Drug Res Inst LDRI, Clin Pharm Res Grp, Brussels, Belgium. | - |
local.description.affiliation | [Henrard, Severine] Catholic Univ Louvain, Inst Hlth & Soc IRSS, Brussels, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Univ Leuven, I BioStat, KU Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Hasselt Univ, I BioStat, Diepenbeek, Belgium. | - |
local.description.affiliation | [Verhaegen, Jan] Univ Hosp Leuven, Natl Reference Ctr Streptococcus Pneumoniae, Leuven, Belgium. | - |
local.description.affiliation | [Verhaegen, Jan] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Mamouris, Pavlos | - |
item.contributor | Henrard, Severine | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Verhaegen, Jan | - |
item.contributor | Lin , Guohao | - |
item.contributor | Vaes , Bert | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2023 | - |
item.fullcitation | Mamouris, Pavlos; Henrard, Severine; MOLENBERGHS, Geert; Verhaegen, Jan; Lin , Guohao & Vaes , Bert (2022) Pneumococcal vaccination prevented severe LRTIs in adults: a causal inference framework applied in registry data. In: JOURNAL OF CLINICAL EPIDEMIOLOGY, 143 , p. 118 -127. | - |
crisitem.journal.issn | 0895-4356 | - |
crisitem.journal.eissn | 1878-5921 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Pneumococcal vaccination prevented severe LRTIs in adults_ a causal inference framework applied in registry data.pdf Restricted Access | Published version | 1.34 MB | Adobe PDF | View/Open Request a copy |
616a.pdf | Peer-reviewed author version | 1.07 MB | Adobe PDF | View/Open |
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