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http://hdl.handle.net/1942/36942
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DC Field | Value | Language |
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dc.contributor.author | KEMPS, Hannelore | - |
dc.contributor.author | Dessy, Chantal | - |
dc.contributor.author | Dumas, Laurent | - |
dc.contributor.author | Sonveaux, Pierre | - |
dc.contributor.author | ALDERS, Lotte | - |
dc.contributor.author | VAN BROECKHOVEN, Jana | - |
dc.contributor.author | Font, Lena Perez | - |
dc.contributor.author | Lambrichts, Sara | - |
dc.contributor.author | Foulquier, Sebastien | - |
dc.contributor.author | HENDRIX, Sven | - |
dc.contributor.author | BRONE, Bert | - |
dc.contributor.author | Lemmens, Robin | - |
dc.contributor.author | BRONCKAERS, Annelies | - |
dc.date.accessioned | 2022-03-21T09:19:40Z | - |
dc.date.available | 2022-03-21T09:19:40Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-03-18T09:53:04Z | - |
dc.identifier.citation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 42 (6) , p. 979-996 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36942 | - |
dc.description.abstract | Extremely low frequency electromagnetic stimulation (ELF-EMS) has been considered as a neuroprotective therapy for ischemic stroke based on its capacity to induce nitric oxide (NO) signaling. Here, we examined whether ELF-EMS reduces ischemic stroke volume by stimulating cerebral collateral perfusion. Moreover, the pathway responsible for ELF-EMS-induced NO production was investigated. ELF-EMS diminished infarct growth following experimental stroke in collateral-rich C57BL/6 mice, but not in collateral-scarce BALB/c mice, suggesting that decreased lesion sizes after ELF-EMS results from improved collateral blood flow. In vitro analysis demonstrated that ELF-EMS increased endothelial NO levels by stimulating the Akt-/eNOS pathway. Furthermore, ELF-EMS augmented perfusion in the hind limb of healthy mice, which was mediated by enhanced Akt-/eNOS signaling. In healthy C57BL/6 mouse brains, ELF-EMS treatment increased cerebral blood flow in a NOS-dependent manner, whereas no improvement in cerebrovascular perfusion was observed in collateral-sparse BALB/c mice. In addition, ELF-EMS enhanced cerebral blood flow in both the contra- and ipsilateral hemispheres of C57BL/6 mice subjected to experimental ischemic stroke. In conclusion, we showed that ELF-EMS enhances (cerebro)vascular perfusion by stimulating NO production, indicating that ELF-EMS could be an attractive therapeutic strategy for acute ischemic stroke by improving cerebral collateral blood flow. | - |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research is supported by the ‘Special Research Funds’ (BOF) of Hasselt University (grants # BOF20TT04 and 18NI06BOF to Annelies Bronckaers and Hannelore Kemps). At UCLouvain, this study was supported by the Fonds National de la Recherche Scientifique (F.R.S.- FNRS, grants # J.0111.17F to Chantal Dessy, and grants # 1.5.141.06 and 1.B181.08 to Pierre Sonveaux). Chantal Dessy and Pierre Sonveaux are Senior Research Associate and Research Director of the F.R.S.-FNRS respectively. Robin Lemmens is a senior clinical investigator of Fonds Wetenschappelijk Onderzoek (FWO) Flanders. The authors would like to send out a word of gratitude to Marc Jans, Evelyne Van Kerckhove, Jeanine Santermans, Thibaut Vazeille, Rachid El Kaddouri, Tim Vangansewinkel, and Laura Ponsaerts for their excellent technical assistance. | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.rights | The Author(s) 2022 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0271678X221084410 journals.sagepub.com/home/jcbfm | - |
dc.subject.other | Akt | - |
dc.subject.other | eNOS pathway | - |
dc.subject.other | cerebral collateral blood flow | - |
dc.subject.other | extremely low frequency electromagnetic stimulation | - |
dc.subject.other | ischemic stroke | - |
dc.subject.other | nitric oxide | - |
dc.title | Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 996 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 979 | - |
dc.identifier.volume | 42 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bronckaers, A (corresponding author), Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | annelies.bronckaers@uhasselt.be | - |
local.publisher.place | 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1177/0271678X221084410 | - |
dc.identifier.pmid | 35209740 | - |
dc.identifier.isi | WOS:000762939000001 | - |
dc.contributor.orcid | Perez, Lena/0000-0003-0242-0765; Kemps, Hannelore/0000-0001-9248-1697 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Kemps, Hannelore; Alders, Lotte; Van Broeckhoven, Jana; Hendrix, Sven; Brone, Bert; Bronckaers, Annelies] Hasselt Univ UHasselt, Biomed Res Inst BIOMED, Diepenbeek, Belgium. | - |
local.description.affiliation | [Dessy, Chantal; Dumas, Laurent; Sonveaux, Pierre] Univ Catholique Louvain UCLouvain, Inst Rech Expt & Clin IREC, Pole Pharmacol & Therapeut, Brussels, Belgium. | - |
local.description.affiliation | [Font, Lena Perez] Univ Oriente, Ctr Nacl Electromagnetismo Aplicado CNEA, Santiago De Cuba, Cuba. | - |
local.description.affiliation | [Lambrichts, Sara; Foulquier, Sebastien] Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, Dept Pharmacol & Toxicol, Maastricht, Netherlands. | - |
local.description.affiliation | [Foulquier, Sebastien] Maastricht Univ, Sch Cardiovasc Dis, CARIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Hendrix, Sven] Med Sch Hamburg, Hamburg, Germany. | - |
local.description.affiliation | [Lemmens, Robin] Univ Leuven, Dept Neurosci, Expt Neurol, KU Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Lemmens, Robin] VIB, Lab Neurobiol, Ctr Brain & Dis Res, Leuven, Belgium. | - |
local.description.affiliation | [Lemmens, Robin] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2023 | - |
item.contributor | KEMPS, Hannelore | - |
item.contributor | Dessy, Chantal | - |
item.contributor | Dumas, Laurent | - |
item.contributor | Sonveaux, Pierre | - |
item.contributor | ALDERS, Lotte | - |
item.contributor | VAN BROECKHOVEN, Jana | - |
item.contributor | Font, Lena Perez | - |
item.contributor | Lambrichts, Sara | - |
item.contributor | Foulquier, Sebastien | - |
item.contributor | HENDRIX, Sven | - |
item.contributor | BRONE, Bert | - |
item.contributor | Lemmens, Robin | - |
item.contributor | BRONCKAERS, Annelies | - |
item.fullcitation | KEMPS, Hannelore; Dessy, Chantal; Dumas, Laurent; Sonveaux, Pierre; ALDERS, Lotte; VAN BROECKHOVEN, Jana; Font, Lena Perez; Lambrichts, Sara; Foulquier, Sebastien; HENDRIX, Sven; BRONE, Bert; Lemmens, Robin & BRONCKAERS, Annelies (2022) Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow. In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 42 (6) , p. 979-996. | - |
crisitem.journal.issn | 0271-678X | - |
crisitem.journal.eissn | 1559-7016 | - |
Appears in Collections: | Research publications |
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Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow.pdf Restricted Access | Published version | 1.44 MB | Adobe PDF | View/Open Request a copy |
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