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Title: | Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow | Authors: | KEMPS, Hannelore Dessy, Chantal Dumas, Laurent Sonveaux, Pierre ALDERS, Lotte VAN BROECKHOVEN, Jana Font, Lena Perez Lambrichts, Sara Foulquier, Sebastien HENDRIX, Sven BRONE, Bert Lemmens, Robin BRONCKAERS, Annelies |
Issue Date: | 2022 | Publisher: | SAGE PUBLICATIONS INC | Source: | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 42 (6) , p. 979-996 | Abstract: | Extremely low frequency electromagnetic stimulation (ELF-EMS) has been considered as a neuroprotective therapy for ischemic stroke based on its capacity to induce nitric oxide (NO) signaling. Here, we examined whether ELF-EMS reduces ischemic stroke volume by stimulating cerebral collateral perfusion. Moreover, the pathway responsible for ELF-EMS-induced NO production was investigated. ELF-EMS diminished infarct growth following experimental stroke in collateral-rich C57BL/6 mice, but not in collateral-scarce BALB/c mice, suggesting that decreased lesion sizes after ELF-EMS results from improved collateral blood flow. In vitro analysis demonstrated that ELF-EMS increased endothelial NO levels by stimulating the Akt-/eNOS pathway. Furthermore, ELF-EMS augmented perfusion in the hind limb of healthy mice, which was mediated by enhanced Akt-/eNOS signaling. In healthy C57BL/6 mouse brains, ELF-EMS treatment increased cerebral blood flow in a NOS-dependent manner, whereas no improvement in cerebrovascular perfusion was observed in collateral-sparse BALB/c mice. In addition, ELF-EMS enhanced cerebral blood flow in both the contra- and ipsilateral hemispheres of C57BL/6 mice subjected to experimental ischemic stroke. In conclusion, we showed that ELF-EMS enhances (cerebro)vascular perfusion by stimulating NO production, indicating that ELF-EMS could be an attractive therapeutic strategy for acute ischemic stroke by improving cerebral collateral blood flow. | Notes: | Bronckaers, A (corresponding author), Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. annelies.bronckaers@uhasselt.be |
Keywords: | Akt;eNOS pathway;cerebral collateral blood flow;extremely low frequency electromagnetic stimulation;ischemic stroke;nitric oxide | Document URI: | http://hdl.handle.net/1942/36942 | ISSN: | 0271-678X | e-ISSN: | 1559-7016 | DOI: | 10.1177/0271678X221084410 | ISI #: | WOS:000762939000001 | Rights: | The Author(s) 2022 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0271678X221084410 journals.sagepub.com/home/jcbfm | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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