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Title: | Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis | Authors: | Garcia-Mendivil, Laura Perez-Zabalza, Maria Mountris, Konstantinos DUWE, Sam SMISDOM, Nick Perez, Marta Lujan, Lluis WOLFS, Esther DRIESEN, Ronald Maria Vallejo-Gil, Jose Carlos Fresneda-Roldan, Pedro Fananas-Mastral, Javier Vazquez-Sancho, Manuel Matamala-Adell, Marta Fernando Sorribas-Berjon, Juan Andre Bellido-Morales, Javier Javier Mancebon-Sierra, Francisco Sebastian Vaca-Nunez, Alexander Ballester-Cuenca, Carlos Olivan-Viguera, Aida Diez, Emiliano Ordovas, Laura Pueyo, Esther |
Issue Date: | 2022 | Publisher: | CELL PRESS | Source: | iScience, 25 (2) (Art N° 103822) | Abstract: | Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. | Notes: | Garcia-Mendivil, L; Ordovas, L (corresponding author), Univ Zaragoza, Aragon Inst Engn Res, Biomed Signal Interpretat & Computat Simulat Grp, Zaragoza 50018, Spain.; Garcia-Mendivil, L; Ordovas, L (corresponding author), IIS Aragon, BSICoS, Zaragoza 50018, Spain.; Ordovas, L (corresponding author), ARAID Fdn, Zaragoza 50018, Spain. lgmendivil@unizar.es; lordovas@unizar.es |
Keywords: | Computational bioinformatics;Disease;Pathophysiology | Document URI: | http://hdl.handle.net/1942/36947 | e-ISSN: | 2589-0042 | DOI: | 10.1016/j.isci.2022.103822 | ISI #: | WOS:000760482200010 | Rights: | 2022 The Author(s). https://doi.org/10.1016/j.isci.2022.103822. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Analysis of age-related left ventricular collagen remodeling in living donors_ Implications in arrhythmogenesis.pdf | Published version | 3.82 MB | Adobe PDF | View/Open |
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