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Title: | Protein Lipidation by Palmitate Controls Macrophage Function | Authors: | GUNS, Jeroen VANHERLE, Sam HENDRIKS, Jerome BOGIE, Jeroen |
Issue Date: | 2022 | Publisher: | MDPI | Source: | CELLS, 11 (3) (Art N° 565) | Abstract: | Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair functions. To accomplish these divergent functions, tremendous dynamic fine-tuning of their physiology is needed. Emerging evidence indicates that S-palmitoylation, a reversible post-translational modification that involves the linkage of the saturated fatty acid palmitate to protein cysteine residues, directs many aspects of macrophage physiology in health and disease. By controlling protein activity, stability, trafficking, and protein-protein interactions, studies identified a key role of S-palmitoylation in endocytosis, inflammatory signaling, chemotaxis, and lysosomal function. Here, we provide an in-depth overview of the impact of S-palmitoylation on these cellular processes in macrophages in health and disease. Findings discussed in this review highlight the therapeutic potential of modulators of S-palmitoylation in immunopathologies, ranging from infectious and chronic inflammatory disorders to metabolic conditions. | Notes: | Bogie, JFJ (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium.; Bogie, JFJ (corresponding author), Hasselt Univ, Univ MS Ctr, B-3500 Hasselt, Belgium. jeroen.guns@student.uhasselt.be; sam.vanherle@uhasselt.be; jerome.hendriks@uhasselt.be; jeroen.bogie@uhasselt.be |
Keywords: | protein acetylation;innate immunity;macrophages;S-palmitoylation;inflammation | Document URI: | http://hdl.handle.net/1942/36998 | e-ISSN: | 2073-4409 | DOI: | 10.3390/cells11030565 | ISI #: | 000760556600001 | Rights: | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Protein Lipidation by Palmitate Controls Macrophage Function.pdf | Published version | 2.22 MB | Adobe PDF | View/Open |
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