Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/37006
Title: | A multicentric validation study of a novel home sleep apnea test based on peripheral arterial tonometry | Authors: | Van Pee, Bart Massie, Frederik Vits, Steven DREESEN, Pauline Klerkx, Susie Bijwadia, Jagdeep Verbraecken, Johan Bergmann, Jeroen |
Issue Date: | 2022 | Publisher: | OXFORD UNIV PRESS INC | Source: | SLEEP, 45 (5) | Abstract: | Study Objectives This paper reports on the multicentric validation of a novel FDA-cleared home sleep apnea test based on peripheral arterial tonometry (PAT HSAT). Methods One hundred sixty-seven participants suspected of having obstructive sleep apnea (OSA) were included in a multicentric cohort. All patients underwent simultaneous polysomnography (PSG) and PAT HSAT, and all PSG data were independently double scored using both the recommended 1A rule for hypopnea, requiring a 3% desaturation or arousal (3% Rule), and the acceptable 1B rule for hypopnea, requiring a 4% desaturation (4% Rule). The double-scoring of PSG enabled a comparison of the agreement between PAT HSAT and PSG to the inter-rater agreement of PSG. Clinical endpoint parameters were selected to evaluate the device's ability to determine the OSA severity category. Finally, a correction for near-boundary apnea-hypopnea index values was proposed to adequately handle the inter-rater variability of the PSG benchmark. Results For both the 3% and the 4% Rules, most endpoint parameters showed a close agreement with PSG. The 4-way OSA severity categorization accuracy of PAT HSAT was strong, but nevertheless lower than the inter-rater agreement of PSG (70% vs 77% for the 3% Rule and 78% vs 81% for the 4% Rule). Conclusions This paper reported on a multitude of robust endpoint parameters, in particular OSA severity categorization accuracies, while also benchmarking clinical performances against double-scored PSG. This study demonstrated strong agreement of PAT HSAT with PSG. The results of this study also suggest that different brands of PAT HSAT may have distinct clinical performance characteristics. | Notes: | Van Pee, B (corresponding author), Nat Interact Lab, Thom Bldg,Pk Rd, Oxford OX1 3PJ, England. Bart.vanpee@eng.ox.ac.uk |
Keywords: | home sleep apnea testing;peripheral arterial tonometry;sympathetic tonedouble-scoring;endpoint design | Document URI: | http://hdl.handle.net/1942/37006 | ISSN: | 0161-8105 | e-ISSN: | 1550-9109 | DOI: | 10.1093/sleep/zsac028 | ISI #: | WOS:000762454800001 | Rights: | Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
A multicentric validation study of a novel home sleep apnea test based on peripheral arterial tonometry.pdf | Published version | 666.35 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
17
checked on Oct 12, 2024
Page view(s)
32
checked on Sep 7, 2022
Download(s)
22
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.