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Title: | Frailty Test Battery Development including Physical, Socio-Psychological and Cognitive Domains for Cardiovascular Disease Patients: A Preliminary Study | Authors: | MARINUS, Nastasia Vigorito, Carlo Giallauria, Francesco DENDALE, Paul MEESEN, Raf Bokken, Kevin Haenen , Laura Jansegers, Thomas Vandenheuvel, Yenthe SCHERRENBERG, Martijn SPILDOOREN, Joke HANSEN, Dominique |
Issue Date: | 2022 | Publisher: | Source: | Journal of Clinical Medicine, 11 (7) (Art N° 1926) | Abstract: | Frailty is an age-related decline in physical, socio-psychological and cognitive function that results in extreme vulnerability to stressors. Therefore, this study aimed to elucidate which tests have to be selected to detect frailty in a comprehensive and feasible manner in cardiovascular disease (CVD) patients based on multivariate regression and sensitivity/specificity analyses. Patients (n = 133, mean age 78 ± 7 years) hospitalised for coronary revascularisation or heart failure (HF) were examined using the Fried and Vigorito criteria, together with some additional measurements. Moreover, to examine the association of frailty with 6-month clinical outcomes, hospitalisations and mortality up to 6 months after the initial hospital admission were examined. Some level of frailty was detected in 44% of the patients according to the Vigorito criteria and in 65% of the patients according to the Fried criteria. Frailty could best be detected by a score based on: sex, Mini Nutritional Assessment (MNA), Katz scale, timed up-and-go test (TUG), handgrip strength, Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS-15) and total number of medications. Frailty and specific markers of frailty were significantly associated with mortality and six-month hospitalisations. We thus can conclude that, in patients with CVD, sex, MNA, Katz scale, TUG, handgrip strength, MMSE, GDS-15 and total number of medications play a key role in detecting frailty, assessed by a new time-and cost-efficient test battery. | Keywords: | frailty;frailty assessment;cardiovascular disease;older adults | Document URI: | http://hdl.handle.net/1942/37121 | e-ISSN: | 2077-0383 | DOI: | 10.3390/jcm11071926 | ISI #: | 000780556300001 | Rights: | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Marinus et al. J Clin Med 2022.pdf | Published version | 707.48 kB | Adobe PDF | View/Open |
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